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Comment
. 2023 Mar;2(3):232-233.
doi: 10.1038/s44161-023-00251-9.

Endothelial tyrosine kinase Tie2 counteracts atherosclerosis development

No authors listed
Comment

Endothelial tyrosine kinase Tie2 counteracts atherosclerosis development

No authors listed. Nat Cardiovasc Res. 2023 Mar.
No abstract available

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Comment on

  • The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium.
    Anisimov A, Fang S, Hemanthakumar KA, Örd T, van Avondt K, Chevre R, Toropainen A, Singha P, Gilani H, Nguyen SD, Karaman S, Korhonen EA, Adams RH, Augustin HG, Öörni K, Soehnlein O, Kaikkonen MU, Alitalo K. Anisimov A, et al. Nat Cardiovasc Res. 2023 Mar 13;2(3):307-321. doi: 10.1038/s44161-023-00224-y. Nat Cardiovasc Res. 2023. PMID: 37476204 Free PMC article.

References

    1. Sack, K. D., Kellum, J. A. & Parikh, S. M. The angiopoietin-Tie2 pathway in critical illness. Crit. Care Clin. 36, 201–216 (2020). A review of the importance of Angpt–Tie in patients who are critically ill. - DOI - PubMed - PMC
    1. Saharinen, P., Eklund, L. & Alitalo, K. Therapeutic targeting of the angiopoietin-TIE pathway. Nat. Rev. Drug Discov. 16, 635–661 (2017). A review article that presents the druggability of the Angpt–Tie signaling pathway. - DOI - PubMed
    1. Porat, R. M. et al. Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies. Circ. Res. 94, 394–401 (2004). This paper shows that disturbed blood flow increases Tie1 expression. - DOI - PubMed
    1. Woo, K. V. et al. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J. Clin. Invest. 121, 1624–1635 (2011). This paper shows that Tie1 attenuation reduces atherosclerosis in Apoe-/- mice.
    1. Theelen, T. L. et al. Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis 241, 297–304 (2015). This paper shows that Angpt2-blocking antibodies reduce atherosclerosis in mice. - DOI - PubMed - PMC

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