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Comment
. 2024 Mar;3(3):265-266.
doi: 10.1038/s44161-024-00443-x.

Taking BETs on cardiomyocyte differentiation

No authors listed
Comment

Taking BETs on cardiomyocyte differentiation

No authors listed. Nat Cardiovasc Res. 2024 Mar.
No abstract available

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Comment on

  • A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.
    Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU, Jain M, Haldar SM, Srivastava D, Jain R. Padmanabhan A, et al. Nat Cardiovasc Res. 2024 Mar;3(3):317-331. doi: 10.1038/s44161-024-00431-1. Epub 2024 Feb 23. Nat Cardiovasc Res. 2024. PMID: 39196112 Free PMC article.

References

    1. Padmanabhan, A. et al. BRD4 (bromodomain-containing protein 4) interacts with GATA4 (GATA binding protein 4) to govern mitochondrial homeostasis in adult cardiomyocytes. Circulation 142, 2338–2355 (2020). This paper shows how BRD4 interacts with tissue-specific transcription factors to mediate cardiomyocyte homeostasis. - DOI - PubMed - PMC
    1. Linares-Saldana, R. et al. BRD4 orchestrates genome folding to promote neural crest differentiation. Nat. Genet. 53, 1480–1492 (2021). This paper elucidates the role of BRD4 in mediating genome folding and its consequences for neural crest differentiation. - DOI - PubMed - PMC
    1. Padmanabhan, A. & Haldar, S. M. Drugging transcription in heart failure. J. Physiol. 598, 3005–3014 (2020). A review article that discusses the therapeutic potential of BET inhibitors. - DOI - PubMed
    1. Kwon, C. et al. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc. Natl Acad. Sci. USA 104, 10894–10899 (2007). This paper reports that WNT signaling is necessary for maintaining cardiac progenitor cells. - DOI - PubMed - PMC
    1. Morton, S. U., Quiat, D., Seidman, J. G. & Seidman, C. E. Genomic frontiers in congenital heart disease. Nat. Rev. Cardiol. 19, 26–42 (2022). A review article that highlights advances in genomic understanding of congenital heart disease. - DOI - PubMed

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