Platelets rejuvenate the aging brain

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Comment

Vesna Todorovic. Nat Cardiovasc Res. 2023 Oct.

. 2023 Oct;2(10):859.

doi: 10.1038/s44161-023-00355-2.

No abstract available

Comment on

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice.
Leiter O, Brici D, Fletcher SJ, Yong XLH, Widagdo J, Matigian N, Schroer AB, Bieri G, Blackmore DG, Bartlett PF, Anggono V, Villeda SA, Walker TL. Leiter O, et al. Nat Commun. 2023 Aug 16;14(1):4375. doi: 10.1038/s41467-023-39873-9. Nat Commun. 2023. PMID: 37587147 Free PMC article.
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.
Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB. Park C, et al. Nat Aging. 2023 Sep;3(9):1067-1078. doi: 10.1038/s43587-023-00468-0. Epub 2023 Aug 16. Nat Aging. 2023. PMID: 37587231 Free PMC article.
Platelet factors attenuate inflammation and rescue cognition in ageing.
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