Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;50(11):1931-1933.
doi: 10.1007/s00134-024-07607-0. Epub 2024 Aug 28.

Quantifying benefit and harm of extracorporeal life support in cardiogenic shock complicating acute myocardial infarction

Christian Jung  1   2 , Bernhard Wernly  3   4   5 , Malte Kelm  6   7 , Uwe Zeymer  8   9 , Holger Thiele  10 ; ECLS shock study group
Collaborators, Affiliations

Quantifying benefit and harm of extracorporeal life support in cardiogenic shock complicating acute myocardial infarction

Christian Jung et al. Intensive Care Med. 2024 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest related to this work.

Figures

Fig. 1
Fig. 1
The figure presents three sets of prior and posterior distributions for Bayesian analysis, each based on different prior assumptions. The prior distribution (dashed line) represents initial beliefs about the log risk ratio before data observation, while the posterior distribution (solid line, green shaded area) shows updated beliefs after data observation. The Region of Practical Equivalence (ROPE) is marked by grey dashed lines from ln(0.9) to ln(1.1), indicating log risk ratios considered practically equivalent to no effect. A magenta dashed line at ln(0.71) represents the threshold for a large benefit (RR < 0.71). The plots include: 1) Non-informative Prior (Mean = 0, SD = ln(10)) and Posterior (Median RR = ln(0.99), 95% Highest Posterior Density (HPD) interval = ln(0.71) to ln(1.25)); 2) Skeptical Prior (Mean = 0, SD = 0.352) and Posterior (Median RR = ln(1.00), 95% HPD = ln(0.79) to ln(1.24)); and 3) Enthusiastic Prior (Mean = − 0.579, SD = 0.352) and Posterior (Median RR = ln(0.89), 95% HPD = ln(0.68) to ln(1.09)). The x-axis displays the log risk ratio and corresponding risk ratios (RR)
See this image and copyright information in PMC

References

    1. Thiele H, Akin I, Sandri M et al (2018) One-year outcomes after PCI strategies in cardiogenic shock. N Engl J Med 379:1699–1710 - PubMed
    1. Ughetto A, Schrage B, Delmas C (2024) Cardiogenic shock in 2024: insight the complex reality of ECLS and left ventricular unloading strategies. Intensive Care Med. 10.1007/s00134-024-07400-z - PubMed
    1. Thiele H, Zeymer U, Akin I et al (2023) Extracorporeal life support in infarct-related cardiogenic shock. N Engl J Med 389:1286–1297 - PubMed
    1. Granholm A, Alhazzani W, Derde LPG et al (2022) Randomised clinical trials in critical care: past, present and future. Intensive Care Med 48:164–178 - PMC - PubMed
    1. Wijeysundera DN, Austin PC, Hux JE et al (2009) Bayesian statistical inference enhances the interpretation of contemporary randomized controlled trials. J Clin Epidemiol 62:13-21.e5 - PubMed

LinkOut - more resources