Next-generation CAR T cell therapies for glioblastoma

Joshua D Bernstock^{1

2

3}, Jakob V E Gerstl¹, Pablo A Valdés⁴, Gregory K Friedman⁵, E Chiocca¹

Affiliations

¹ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
³ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴ Department of Neurosurgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
⁵ Division of Pediatrics, Neuro-Oncology Section, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 39196960
DOI: 10.1126/scitranslmed.adp2660

Review

Next-generation CAR T cell therapies for glioblastoma

Joshua D Bernstock et al. Sci Transl Med. 2024.

. 2024 Aug 28;16(762):eadp2660.

doi: 10.1126/scitranslmed.adp2660. Epub 2024 Aug 28.

Authors

Joshua D Bernstock^{1

2

3}, Jakob V E Gerstl¹, Pablo A Valdés⁴, Gregory K Friedman⁵, E Chiocca¹

Affiliations

¹ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
³ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴ Department of Neurosurgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
⁵ Division of Pediatrics, Neuro-Oncology Section, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 39196960
DOI: 10.1126/scitranslmed.adp2660

Abstract

Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).

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Next-generation CAR T cell therapies for glioblastoma

Affiliations

Next-generation CAR T cell therapies for glioblastoma

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources