Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2024 Sep 3;84(10):921-933.
doi: 10.1016/j.jacc.2024.04.070.

Continuous Rhythm Monitoring With Implanted Loop Recorders in Children and Adolescents With Brugada Syndrome

Marco Bergonti  1 , Giuseppe Ciconte  2 , Jose Cruzalegui Gomez  3 , Lia Crotti  4 , Elena Arbelo  5 , Michela Casella  6 , Johan Saenen  7 , Andrea Rossi  8 , Luigi Pannone  9 , Estefania Martinez-Barrios  3 , Paolo Compagnucci  6 , Vincenzo Russo  10 , Paola Berne  11 , Olivier Van Leuven  7 , Antonio Boccellino  2 , Lorenzo Marcon  12 , Federica Dagradi  13 , Federico Landra  8 , Tardu Özkartal  1 , Angelo Comune  10 , Sergio Conti  14 , Valentina Ribatti  12 , Oscar Campuzano  15 , Pedro Brugada  9 , Carlo de Asmundis  9 , Josep Brugada  5 , Carlo Pappone  2 , Claudio Tondo  12 , Peter J Schwartz  13 , Angelo Auricchio  16 , Georgia Sarquella-Brugada  17 , Giulio Conte  18
Affiliations
Free article
Multicenter Study

Continuous Rhythm Monitoring With Implanted Loop Recorders in Children and Adolescents With Brugada Syndrome

Marco Bergonti et al. J Am Coll Cardiol. .
Free article

Abstract

Background: Young (<18 years of age) patients with Brugada syndrome (BrS) are often under-represented in BrS studies and their management, especially related to syncopal episodes, remains unclear.

Objectives: This study sought to describe the arrhythmia prevalence among young patients with BrS undergoing continuous rhythm monitoring by implantable loop recorder (ILR) and to assess the etiology behind syncope of undetermined origin.

Methods: A total of 147 patients with BrS with ILR were enrolled in 12 international centers and divided into pediatric (age <12 years; n = 77, 52%) and adolescents (age 13-18 years; n = 70, 48%).

Results: Mean age was 11.3 years, 53 patients (36.1%) were female, and 31 (21.1%) had spontaneous type 1 electrocardiograms. Over a median follow-up of 3.6 years (Q1-Q3: 1.6-4.8 years), an arrhythmic event was recorded in 33 patients (22.4%), mainly of nonventricular origin: 15 atrial (10.2%) and 16 bradyarrhythmic events (10.9%). Ventricular arrhythmias occurred in 4 patients, all with spontaneous BrS, and were fever-related in one-half. Among all patients with recurrence of syncope during follow-up, true arrhythmic syncope was documented in 5 (17.8%), and it was due to bradyarrhythmias or atrial arrhythmias in 3 cases (60%).

Conclusions: Continuous rhythm monitoring with ILRs in young patients with BrS detects a broad range of arrhythmias. Ventricular arrhythmias occur predominantly in patients with spontaneous type 1 electrocardiograms and during fever. Despite the young age, bradyarrhythmias and atrial arrhythmias are frequent and represent the cause of arrhythmic syncope in 60% of patients. Young patients with BrS with syncope of undetermined origin may benefit from ILR implant.

Keywords: Brugada syndrome; adolescent; atrial arrhythmias; bradyarrhythmias; implantable loop recorder; pediatric; rhythm monitoring; sudden cardiac death; syncope; ventricular arrhythmias; young.

PubMed Disclaimer

Conflict of interest statement

Funding Support and Author Disclosures This study was fully supported by a research grant of the Swiss National Science Foundation (PZ00P3_180055). Dr Özkartal has received research grants from Medtronic and Philips; and has received speaker fees from MicroPort CRM. Dr P. Brugada has received compensation for teaching purposes from Biotronik. Dr de Asmundis has received research grants on behalf of the center from Biotronik, Medtronic, Abbott, LivaNova, Boston Scientific, AtriCure, Philips, and Acutus Medical; and has received compensation for teaching purposes and proctoring from Medtronic, Abbott, Biotronik, LivaNova, Boston Scientific, AtriCure, Acutus Medical, and Daiichi-Sankyo. Dr Tondo has served on the Advisory Boards of Medtronic and Boston Scientific; and has received lecture and grant travel fees from Medtronic, Abbott Medical, Boston Scientific, and AtriCure. Dr Auricchio has served as a consultant to Boston Scientific, Cairdac, Corvia, MicroPort CRM, EPD-Philips, and Radcliffe Publisher; has received speaker fees from Boston Scientific, Medtronic, and MicroPort CRM; has participated in clinical trials sponsored by Boston Scientific, Medtronic, and EPD-Philips; and has intellectual properties with Boston Scientific, Biosense Webster, and MicroPort CRM. Dr Conte has received a research grant (PZ00P3_180055) from the Swiss National Science Foundation. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publication types

LinkOut - more resources