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. 2024 Aug 28;24(1):457.
doi: 10.1186/s12872-024-04129-x.

Severe bronchiectasis is associated with increased carotid intima-media thickness

Wang Chun Kwok #  1 , Kui Kai Lau #  1   2 , Kay Cheong Teo  1 , Sze Him Isaac Leung  3 , Chung Ki Tsui  1 , Matthew S S Hsu  4 , Kkts Pijarnvanit  1 , Carman Nga-Man Cheung  1 , Yick Hin Chow  1 , James Chung Man Ho  5
Affiliations

Severe bronchiectasis is associated with increased carotid intima-media thickness

Wang Chun Kwok et al. BMC Cardiovasc Disord. .

Abstract

Background: Although bronchiectasis has been shown to be associated with cardiovascular disease, there is limited evidence of an association with subclinical atherosclerosis, especially carotid intima-media thickness (CIMT).

Methods: This prospective study compared CIMT among patients with and without bronchiectasis, and among bronchiectatic patients classified according to disease severity using the FACED score. The study was carried out at a major regional hospital and tertiary respiratory referral centre in Hong Kong.

Results: Total 155 Chinese patients with non-cystic fibrosis (CF) bronchiectasis and 512 controls were recruited. The mean CIMT was 0.58 ± 0.10 mm, 0.63 ± 0.11 mm and 0.66 ± 0.08 mm respectively among controls, patients with mild-to-moderate bronchiectasis and patients with severe bronchiectasis. There was no statistically significant difference in CIMT between patients with mild-to-moderate bronchiectasis and controls. Multivariate linear regression revealed that CIMT was significantly increased in patients with severe bronchiectasis relative to controls. The same phenomenon was observed among patients without a history of cardiovascular disease or cardiovascular risk factors.

Conclusions: CIMT was significantly increased in patients with severe bronchiectasis compared with controls without bronchiectasis, but not among patients with mild-to-moderate bronchiectasis, which suggested the subclinical atherosclerosis to be more prevalent among patients with severe bronchiectasis.

Keywords: Bronchiectasis; Cardiovascular disease; Carotid initial thickness; Subclinical atherosclerosis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mean CIMT among all patients with mild-to-moderate bronchiectasis, severe bronchiectasis, and controls in the whole cohort. CIMT are compared by one-way ANOVA. CIMT: Carotid intima-media thickness
Fig. 2
Fig. 2
Mean CIMT among patients with mild-to-moderate bronchiectasis, severe bronchiectasis, and controls with no cardiovascular risk factors or history of cardiovascular diseases in the whole cohort. CIMT are compared by one-way ANOVA. CIMT: Carotid intima-media thickness
See this image and copyright information in PMC

References

    1. Boyton RJ, Altmann DM. Bronchiectasis: current concepts in Pathogenesis, Immunology, and Microbiology. Annu Rev Pathol. 2016;11:523–54. 10.1146/annurev-pathol-012615-044344 - DOI - PubMed
    1. Koenig W, Sund M, Frohlich M, et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring trends and determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99(2):237–42. 10.1161/01.CIR.99.2.237 - DOI - PubMed
    1. Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation. 1998;98(8):731–3. 10.1161/01.CIR.98.8.731 - DOI - PubMed
    1. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation. 1998;97(20):2007–11. 10.1161/01.CIR.97.20.2007 - DOI - PubMed
    1. Force USPST, Curry SJ, Krist AH, et al. Risk Assessment for Cardiovascular Disease with nontraditional risk factors: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;320(3):272–80. 10.1001/jama.2018.8359 - DOI - PubMed

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