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. 2024 Aug;28(16):e70007.
doi: 10.1111/jcmm.70007.

Triglyceride-glucose index and clinical outcomes in sepsis: A retrospective cohort study of MIMIC-IV

Yan Cao  1 , Liudang He  2 , Yingjie Su  2 , Ju Luo  3 , Ning Ding  2
Affiliations

Triglyceride-glucose index and clinical outcomes in sepsis: A retrospective cohort study of MIMIC-IV

Yan Cao et al. J Cell Mol Med. 2024 Aug.

Abstract

Although accumulating researches were done for investigating the relationship between triglyceride-glucose index (TyG index) and different diseases, none of the researches have been made in sepsis yet. In this study, we aimed to explore the relationship between TyG index and clinical outcomes in sepsis based on a large critical care public database. Sepsis patients in Medical Information Mart for Intensive Care IV (MIMIC-IV) Database were included. The exposure was TyG index, which was calculated by the equation: ln (TG (mg/dL) × FBG (mg/dL)/2). The outcomes were in-hospital mortality and 1-year mortality. The relationship between TyG index and outcomes was performed by Cox regression analysis. Smooth fitting curves were constructed by using generalized additive model. Kaplan-Meier analyses for cumulative hazard of 1-year mortality in different groups were done. 1103 sepsis patients were included with a median TyG index of 9.78. The mortalities of in-hospital and 1-year were 37.53% (n = 414) and 42.25% (n = 466), respectively. After adjusting confounders, there was a significantly negative relationship between TyG index and mortalities of in-hospital and 1-year. With the per unit increment in TyG index, the risk of in-hospital and 1-year mortality both decreased by 21% (HR = 0.79, 95% CI: 0.66-0.94, p = 0.0086 and HR = 0.79, 95% CI: 0.66-0.94, p = 0.0080, respectively). A negative relationship between TyG index and clinical outcomes in sepsis was found.

Keywords: MIMIC‐IV; mortality; sepsis; triglyceride‐glucose index.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
Smooth fitting curves demonstrated the associations between TyG index and mortalities of in‐hospital (A) and 1‐year (B).
FIGURE 2
FIGURE 2
Kaplan–Meier analysis for cumulative hazard of 1‐year mortality in sepsis based on tertiles (A) and quartiles (B) of TyG index.
See this image and copyright information in PMC

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