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Review
. 2024 Jul 29;13(8):919.
doi: 10.3390/antiox13080919.

Marine Antioxidants from Marine Collagen and Collagen Peptides with Nutraceuticals Applications: A Review

Emin Cadar  1 , Ana-Maria Pesterau  2 , Irina Prasacu  3 , Ana-Maria Ionescu  4   5 , Carolina Pascale  2 , Ana-Maria Laura Dragan  2 , Rodica Sirbu  2 , Cezar Laurentiu Tomescu  4   6
Affiliations
Review

Marine Antioxidants from Marine Collagen and Collagen Peptides with Nutraceuticals Applications: A Review

Emin Cadar et al. Antioxidants (Basel). .

Abstract

Collagen peptides and marine collagen are enormous resources currently utilized. This review aims to examine the scientific literature to determine which collagen peptides derived from marine sources and which natural active antioxidants from marine collagen have significant biological effects as health-promoting nutraceuticals. Marine collagen is extracted from both vertebrate and invertebrate marine creatures. For vertebrates, this includes fish skin, bones, scales, fins, and cartilage. For invertebrates, it includes mollusks, echinoderms, crustaceans, and poriferans. The method used involved data analysis to organize information for isolating and identifying marine biocompounds with antioxidant properties. Specifically, amino acids with antioxidant properties were identified, enabling the use of hydrolysates and collagen peptides as natural antioxidant nutraceuticals. The methods of extraction of hydrolyzed collagen and collagen peptides by different treatments are systematized. The structural characteristics of collagen, collagen peptides, and amino acids in fish skin and by-products, as well as in invertebrate organisms (jellyfish, mollusks, and crustaceans), are described. The antioxidant properties of different methods of collagen hydrolysates and collagen peptides are systematized, and the results are comparatively analyzed. Their use as natural antioxidant nutraceuticals expands the range of possibilities for the exploitation of natural resources that have not been widely used until now.

Keywords: marine antioxidant; marine collagen; marine collagen peptides; marine nutraceuticals.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Marine sources for the preparation of marine collagen.
Figure 2
Figure 2
Scheme for obtaining marine collagen through (A) acid-soluble collagen method; (B) pepsin-soluble collagen method and (C) collagen peptides.
Figure 3
Figure 3
Advantages and disadvantages of marine collagen extraction procedures.
Figure 4
Figure 4
Structure of collagen fibers, collagen fibrils, and amino acid chains. Reprinted with permission from reference [34], 2023, Emin Cadar.
Figure 5
Figure 5
Amino acids (EAA) in marine-derived collagen and collagen peptides.
Figure 6
Figure 6
Type of methods used to demonstrate antioxidant activity.
Figure 7
Figure 7
Diseases treated with antioxidant nutraceuticals that have in their compositions peptides and collagen hydrolysates.
See this image and copyright information in PMC

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