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. 2024 Aug 14;13(8):983.
doi: 10.3390/antiox13080983.

Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial

Colin J Gimblet  1 , Nicholas T Kruse  2 , Katharine Geasland  3 , Jeni Michelson  3 , Mingyao Sun  1 , Patrick Ten Eyck  3 , Cari Linkenmeyer  4 , Safur Rehman Mandukhail  1 , Matthew J Rossman  5 , Meenakshi Sambharia  1 , Michel Chonchol  6 , Manjula Kurella Tamura  7   8 , Douglas Seals  5 , Karin F Hoth  4   9 , Diana Jalal  1   10
Affiliations

Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial

Colin J Gimblet et al. Antioxidants (Basel). .

Abstract

Chronic kidney disease (CKD) increases the risk of cardiovascular disease and cognitive impairment. Curcumin is a polyphenol that improves vascular and cognitive function in older adults; however, its effects on vascular and cognitive function in patients with CKD are unknown. We hypothesized that curcumin supplementation would improve vascular and cognitive function in patients with CKD. Eighty-eight adults diagnosed with stage 3b or 4 CKD (aged 66 ± 8 years, 75% male) participated in a 12-month, randomized, double-blind, placebo-controlled study to test the effects of curcumin (Longvida®, 2000 mg/day) on vascular and cognitive function. Our primary outcome was brachial artery flow-mediated dilation (FMD). Our secondary outcomes were nitroglycerin-mediated dilation, carotid-femoral pulse wave velocity (cfPWV), and cognitive function assessed via the NIH Toolbox Cognition Battery. At baseline, the mean estimated glomerular filtration rate was 34.7 ± 10.8, and the median albumin/creatinine ratio was 81.9 (9.7, 417.3). A total of 44% of participants had diabetes. Compared with placebo, 12 months of curcumin did not improve FMD (median change from baseline was -0.7 (-2.1, 1.1) and -0.1 (-1.5, 1.5) for curcumin and placebo, respectively, with p = 0.69). Similarly, there were no changes in nitroglycerin-mediated dilation, cfPWV, or cognitive outcomes. These results do not support chronic curcumin supplementation to improve vascular and cognitive function in patients with CKD.

Keywords: CKD; curcumin; oxidative stress; vascular function.

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Conflict of interest statement

None of the authors have conflicts of interest.

Figures

Figure 1
Figure 1
Study schema.
Figure 2
Figure 2
Brachial artery flow-mediated dilation at baseline, 6 months, and 12 months according to study group. Data are presented as median (interquartile range). A Wilcoxon Rank-Sum test was used to compare the change in brachial artery flow-mediated dilation between groups at 6 and 12 months. BL, baseline; 6M, 6 months; 12M, 12 months.
See this image and copyright information in PMC

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