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. 2024 Aug 18;13(8):998.
doi: 10.3390/antiox13080998.

Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study

Marco Fiore  1 , Chiara Cambieri  2 , Laura Libonati  2 , Federica Moret  2 , Edoardo D'Andrea  2 , Maria Grazia Di Certo  1 , Claudio Passananti  3 , Francesca Gabanella  1 , Nicoletta Corbi  3 , Matteo Garibaldi  4 , Cristina Chimenti  5 , Maria Alfarano  5 , Giampiero Ferraguti  6 , Silvia Francati  6 , Maurizio Inghilleri  2   7 , Marco Ceccanti  2
Affiliations

Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study

Marco Fiore et al. Antioxidants (Basel). .

Abstract

Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv, "v" for variant) and wild-type (ATTRwt) forms are known. Beyond the steric encumbrance, precipitated transthyretin seems to have a toxic effect. In this study carried out in men, we recruited 15 ATTRv patients, 7 ATTRv asymptomatic carriers, 14 ATTRwt patients and 10 young and 13 old healthy controls to evaluate the oxidative stress using FORD (Free Oxygen Radicals Defense) and FORT (Free Oxygen Radicals Test) analyses. ATTRv patients showed reduced FORD compared to ATTRwt and ATTRv asymptomatic carriers. FORD independently predicted the disease stage, with the early stages characterized by the highest consumption. These findings suggest a role for oxidative stress in the early stages of ATTRv.

Keywords: FORD; FORT; amyloidosis; oxidative stress; transthyretin.

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Conflict of interest statement

All the authors unequivocally declare that there are no conflicts of interest concerning this research.

Figures

Figure 1
Figure 1
FORD levels in the different groups. * p < 0.05. Boxes indicate upper and lower quartiles, and whiskers indicate the minimum to the maximum value.
Figure 2
Figure 2
FORD levels in the different FAP stages. * p < 0.05. Boxes indicate upper and lower quartiles, and whiskers indicate the minimum to the maximum value.
See this image and copyright information in PMC

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