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Review
. 2024 Aug 20;12(8):1913.
doi: 10.3390/biomedicines12081913.

Nesfatin-1: A Novel Diagnostic and Prognostic Biomarker in Digestive Diseases

Adriana-Cezara Damian-Buda  1 , Daniela Maria Matei  2   3 , Lidia Ciobanu  2   3 , Dana-Zamfira Damian-Buda  3 , Raluca Maria Pop  4 , Anca Dana Buzoianu  4 , Ioana Corina Bocsan  4
Affiliations
Review

Nesfatin-1: A Novel Diagnostic and Prognostic Biomarker in Digestive Diseases

Adriana-Cezara Damian-Buda et al. Biomedicines. .

Abstract

Nesfatin-1, deriving from a precursor protein, NUCB2, is a newly discovered molecule with anti-apoptotic, anti-inflammatory, antioxidant, and anorexigenic effects. It was initially identified in the central nervous system (CNS) and received increasing interest due to its energy-regulating properties. However, research showed that nesfatin-1 is also expressed in peripheral tissues, including the digestive system. The aim of this review is to give a résumé of the present state of knowledge regarding its structure, immunolocalization, and potential implications in diseases with inflammatory components. The main objective was to focus on its clinical importance as a diagnostic biomarker and potential therapeutic molecule in a variety of disorders, among which digestive disorders were of particular interest. Previous studies have shown that nesfatin-1 regulates the balance between pro- and antioxidant agents, which makes nesfatin-1 a promising therapeutic agent. Further in-depth research regarding the underlying mechanisms of action is needed for a better understanding of its effects.

Keywords: anorexigenic; anti-inflammatory; antioxidant; digestive disorders; inflammatory disorders; nesfatin-1.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Nesfatin-1: localization and possible role in tissue functions regulation. Created with BioRender.com (accessed on 1 August 2024).
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