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Review
. 2024 Aug 12;13(16):4733.
doi: 10.3390/jcm13164733.

Role of Cardiac Magnetic Resonance in Inflammatory and Infiltrative Cardiomyopathies: A Narrative Review

Davide Marchetti  1 , Federica Buzzi  2 , Riccardo Di Febo  2 , Sara Modugno  1 , Matteo Schillaci  1 , Pasquale Paolisso  1 , Marco Doldi  1 , Eleonora Melotti  1 , Angelo Ratti  1 , Andrea Provera  2 , Gianluca Guarnieri  2 , Riccardo Terzi  2 , Michele Gallazzi  2 , Edoardo Conte  1 , Daniele Andreini  1   3
Affiliations
Review

Role of Cardiac Magnetic Resonance in Inflammatory and Infiltrative Cardiomyopathies: A Narrative Review

Davide Marchetti et al. J Clin Med. .

Abstract

Cardiac magnetic resonance (CMR) has acquired a pivotal role in modern cardiology. It represents the gold standard for biventricular volume and systolic function assessment. Moreover, CMR allows for non-invasive myocardial tissue evaluation, highlighting tissue edema, fibrosis, fibro-fatty infiltration and iron overload. This manuscript aims to review the impact of CMR in the main inflammatory and infiltrative cardiomyopathies, providing details on specific imaging patterns and insights regarding the most relevant trials in the setting.

Keywords: Anderson–Fabry disease; amyloidosis; cardiac magnetic resonance imaging; cardiac sarcoidosis; cardiomiopathy; infiltrative diseases; inflammation; iron overload; systemic disease.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
“Hot phase” presentation of NDLVC—short axis cine FIESTA (A), short axis LGE sequence showing basal posterior septal intramyocardial enhancement (highlighted with arrows) (B) with elevated T1 (C) and T2 times (D).
Figure 2
Figure 2
“Hot phase” presentation of DCM—short axis LGE sequence septal intramyocardial enhancement (A) with elevated ECM (B), T1 (C) and T2 times (D).
Figure 3
Figure 3
Biventricular ARVC—short axis LGE sequence (A) and long axis LGE sequence (B) showing diffuse intramyocardial enhancement involving left and right ventricles (LGE highlighted with arrows) with elevated T1 times (C).
Figure 4
Figure 4
HCM—FIESTA four-chamber view showing LV hypertrophy (A) with mild enhancement LGE highlighted with arrows) and elevated T1 times in hypertrophic segments (B,C).
Figure 5
Figure 5
Cardiac sarcoidosis—short axis LGE sequence (A) showing focal septal intramyocardial enhancement with elevated T1 times (B) and T2 times (C).
Figure 6
Figure 6
Cardiac amyloidosis—long axis LGE sequence (A) showing diffuse sub-epicardial enhancement involving the atria and left and right ventricles with diffuse markedly elevated T1 times (B) and ECV (C).
Figure 7
Figure 7
Anderson–Fabry disease—short axis FIESTA sequence showing concentric hypertrophy (A), typical basal inferolateral intramyocardial enhancement (LGE highlighted with arrows) (B) with markedly reduced T1 times (C) and elevated T2 times in inferolateral segments (D).
See this image and copyright information in PMC

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