Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Apr;48(1):139-45.
doi: 10.1128/iai.48.1.139-145.1985.

Adhesion of a human fecal Escherichia coli strain to mouse colonic mucus

P S Cohen, J C Arruda, T J Williams, D C Laux

Adhesion of a human fecal Escherichia coli strain to mouse colonic mucus

P S Cohen et al. Infect Immun. 1985 Apr.

Abstract

Escherichia coli F-18 isolated from the feces of a healthy human is an excellent colonizer of the CD-1 mouse colon. In the present investigation, adhesion of E. coli F-18 to CD-1 mouse colonic mucus and bovine serum albumin (BSA), immobilized on polystyrene, was studied. Adhesion of E. coli F-18 to mucus was two- to sixfold greater than to either BSA or polystyrene. E. coli F-18 lipopolysaccharide specifically blocked adhesion of E. coli F-18 to mucus and mimicked adhesion of E. coli F-18 to mucus, BSA, and polystyrene. Purified capsule also blocked adhesion of E. coli F-18 to mucus, but this inhibition was found to be entirely nonspecific. The specific E. coli F-18 receptor in mucus appeared to be a glycoprotein, containing sugars normally found in mucins and having a maximum molecular weight of between 1.25 X 10(5) and 2.5 X 10(5).

PubMed Disclaimer

References

    1. J Gen Microbiol. 1983 May;129(5):1549-58 - PubMed
    1. Digestion. 1978;17(3):234-63 - PubMed
    1. Infect Immun. 1981 Oct;34(1):241-9 - PubMed
    1. Infect Immun. 1979 Jan;23(1):128-32 - PubMed
    1. J Bacteriol. 1974 Jul;119(1):138-43 - PubMed

Publication types