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Review
. 2024 Aug 16;25(16):8936.
doi: 10.3390/ijms25168936.

Atopic Dermatitis and Autism Spectrum Disorders: Common Role of Environmental and Clinical Co-Factors in the Onset and Severity of Their Clinical Course

Rossella Casella  1 , Andrea Miniello  1 , Federica Buta  2 , Mona-Rita Yacoub  3 , Eustachio Nettis  1 , Giovanni Pioggia  4 , Sebastiano Gangemi  2
Affiliations
Review

Atopic Dermatitis and Autism Spectrum Disorders: Common Role of Environmental and Clinical Co-Factors in the Onset and Severity of Their Clinical Course

Rossella Casella et al. Int J Mol Sci. .

Abstract

Increasing evidence suggests an association between atopic dermatitis, the most chronic inflammatory disease of the skin, and autism spectrum disorders, which are a group of neurodevelopmental diseases. Inflammation and immune dysregulation associated with genetic and environmental factors seem to characterize the pathophysiological mechanisms of both conditions. We conducted a literature review of the PubMed database aimed at identifying the clinical features and alleged risk factors that could be used in clinical practice to predict the onset of ASD and/or AD or worsen their prognosis in the context of comorbidities.

Keywords: ADHD; atopic dermatitis; autism spectrum disorders; exposome; genetic.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Common role of environmental (pregnancy, air pollutants, drugs, stress, diet), genetic predisposition and clinical co-factors (male sex and >5 years and/or 6–11 years old groups) in the production of inflammation which cause the onset and severity of the clinical course of patients affected by ASD and AD.
Figure 2
Figure 2
The timeline of research on the link between atopic comorbidities and autism spectrum disorders [49,50,51,54,56,58,75,90,92,93].
See this image and copyright information in PMC

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