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Review
. 2024 Aug 16;11(8):1004.
doi: 10.3390/children11081004.

Acute Kidney Injury in Children: A Focus for the General Pediatrician

Giulio Rivetti  1 , Pietro Gizzone  1 , Delfina Petrone  1 , Anna Di Sessa  1 , Emanuele Miraglia Del Giudice  1 , Stefano Guarino  1 , Pierluigi Marzuillo  1
Affiliations
Review

Acute Kidney Injury in Children: A Focus for the General Pediatrician

Giulio Rivetti et al. Children (Basel). .

Abstract

Acute kidney injury (AKI) presents significant challenges in pediatric care, often remaining underrecognized. This paper provides an overview of pediatric AKI, highlighting its epidemiology, pathophysiology, diagnosis, predisposing conditions, and treatment. AKI in children stems from diverse causes, including renal tubular damage, vasoconstriction, and inflammation. Diagnosis relies on traditional markers such as serum creatinine and urine output, alongside emerging biomarkers such as Cystatin C, NGAL, KIM-1, IL-18, TIMP-2 and IGFBP7, urinary calprotectin, URBP4, L-FABP, and clusterin. Various pediatric conditions predispose to AKI, including type 1 diabetes, pneumonia, bronchiolitis, appendicitis, gastroenteritis, COVID-19, multisystem inflammatory syndrome, sickle cell disease, and malignancies. Treatment entails supportive care with fluid management and, in severe cases, renal replacement therapy. Timely recognition and management are essential to mitigating adverse outcomes. Enhanced awareness and integration of novel biomarkers could improve pediatric AKI care, warranting further research for better diagnosis and management.

Keywords: acute kidney injury; biomarkers; children; chronic kidney disease.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Causes and prevalence of AKI in children hospitalized for several diseases (from references [6,20,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40].
Figure 2
Figure 2
Classification and pathophysiology of AKI on the basis of the novel biomarkers.
See this image and copyright information in PMC

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