A Systematic Review Evaluating the Diagnostic Efficacy of Narrow-Band Imaging for Laryngeal Cancer Detection

Abstract

Background: Narrow-band imaging is an advanced endoscopic technology used to detect changes on the laryngeal tissue surface, employing a comparative approach alongside white-light endoscopy to facilitate histopathological examination. Objective: This study aimed to assess the utility and advantages of NBI (narrow-band imaging) in identifying malignant laryngeal lesions through a comparative analysis with histopathological examination. Methods: We conducted a systematic literature review, utilizing databases such as PubMed, the CNKI database, and Embase for our research. Results: We analyzed the articles by reviewing their titles and abstracts, selecting those we considered relevant based on determined criteria; in the final phase, we examined the relevant studies according to the specific eligibility criteria. Conclusions: Narrow-band imaging is an advanced endoscopic technology that demonstrates its efficacy as a tool for diagnosing malignant laryngeal lesions and comparing them to premalignant lesions. The European Society of Laryngology has implemented a standardized classification system for laryngeal lesions to enhance data correlation and organization.

Keywords: NBI; laryngeal cancer; laryngeal carcinoma; laryngeal neoplasms; larynx cancer; larynx carcinoma; narrow-band imaging.

Figure 1

Evaluation of methodological quality using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) framework.

Figure 2

Evaluation of methodological quality using QUADAS-2 framework—percentage.

Figure 3

A flow chart of the article selection process.

Figure 4

Forest plot for specificity of NBI [22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38].

Figure 5

Forest plot for sensitivity of NBI [23,24,25,27,28,29,34,35,37].