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Randomized Controlled Trial
. 2024 Jul 25;60(8):1206.
doi: 10.3390/medicina60081206.

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling, and Trismus after Impacted Lower Third Molar Surgery: Randomised Clinical Trial

Volkan Kaplan  1 , Levent Ciğerim  2 , Erkan Feslihan  1 , Saadet Çınarsoy Ciğerim  3
Affiliations
Randomized Controlled Trial

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling, and Trismus after Impacted Lower Third Molar Surgery: Randomised Clinical Trial

Volkan Kaplan et al. Medicina (Kaunas). .

Abstract

Background and Objectives: The aim of this study was to investigate the efficacy of a single preoperative dose of deflazacort on pain, swelling, and trismus after impacted lower third molar surgery. Materials and Methods: This randomised, prospective, double-blind, split-mouth clinical study included 26 healthy individuals with bilaterally impacted lower third molars. Group 1 was given a placebo (single-dose vitamin C tablet), and group 2 was given a single 30 mg dose of deflazacort 1 h prior to surgery. Pain was evaluated using the visual analogue scale for 1 week postoperatively. Oedema (in mm) and trismus (in mm) were evaluated preoperatively and on postoperative days 2 and 7. The Mann-Whitney U test was applied for group analyses. p values < 0.05 were considered statistically significant. Results: Postoperative pain scores were significantly lower in the deflazacort group at the 6th and 12th hours after surgery (p < 0.05). There were no significant differences in trismus between the groups at any time point (p > 0.05). There was less oedema in the deflazacort group on postoperative days 2 and 7, without any statistically significant difference (p > 0.05). Conclusions: A single preoperative dose of 30 mg deflazacort was found to be clinically effective in reducing pain and oedema after extraction of impacted lower third molars.

Keywords: corticosteroid; deflazacort; impacted third molar surgery; pain; swelling; trismus.

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Conflict of interest statement

The authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Measurement of Mouth Opening.
Figure 2
Figure 2
Facial landmarks for assessment of oedema.
Figure 3
Figure 3
VAS Scale for assessment of postoperative pain.
See this image and copyright information in PMC

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