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Review
. 2024 Aug 11;12(8):1642.
doi: 10.3390/microorganisms12081642.

The Role of Postbiotics in Asthma Treatment

Konstancja Węgrzyn  1 , Agnieszka Jasińska  2 , Kamil Janeczek  3 , Wojciech Feleszko  2
Affiliations
Review

The Role of Postbiotics in Asthma Treatment

Konstancja Węgrzyn et al. Microorganisms. .

Abstract

In recent years, there has been abundant research concerning human microbiome and its impact on the host's health. Studies have shown that not only the commensal bacteria itself, but also postbiotics, understood as inanimate microorganisms, possibly with the presence of their components, may themselves have an effect on various elements of human physiology. In this review, we take a closer look at the specific ways in which postbiotics can alter immune response in allergic asthma, which is one of the most prevalent allergic diseases in today's world and a serious subject of concern. Through altering patients' immune response, not only to allergens but also to pathogens, postbiotics could have a significant role in lowering the number of asthma exacerbations. We suggest that more profound research should be undertaken in order to launch postbiotics into clinical standards of asthma treatment, given the greatly promising findings in terms of their immunomodulating potential.

Keywords: allergic asthma; bacterial lysates; immunomodulation; microbiome; postbiotics.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Immunomodulatory properties of postbiotics. Postbiotics act as immunomodulators and promote antiallergic immune responses. They provide the maintenance of violated Th1/Th2 type immune response balance, stimulate IgA and IgG production, and provoke DC maturation. Moreover, they reduce asthma symptoms by decreasing mast cell degranulation and eosinophil count. Created with biorender.com. HKL—Heat-Killed Lactobacillus.
Figure 2
Figure 2
Identification of studies via databases.
See this image and copyright information in PMC

References

    1. Weinberger M. Can we prevent exacerbations of asthma caused by common cold viruses? J. Allergy Clin. Immunol. 2010;126:770–771. doi: 10.1016/j.jaci.2010.08.019. - DOI - PubMed
    1. Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B., Morelli L., Canani R.B., Flint H.J., Salminen S., et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66. - DOI - PubMed
    1. Gibson G.R., Hutkins R., Sanders M.E., Prescott S.L., Reimer R.A., Salminen S.J., Scott K., Stanton C., Swanson K.S., Cani P.D., et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat. Rev. Gastroenterol. Hepatol. 2017;14:491–502. doi: 10.1038/nrgastro.2017.75. - DOI - PubMed
    1. Salminen S., Collado M.C., Endo A., Hill C., Lebeer S., Quigley E.M.M., Sanders M.E., Shamir R., Swann J.R., Szajewska H., et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat. Rev. Gastroenterol. Hepatol. 2021;18:649–667. doi: 10.1038/s41575-021-00440-6. - DOI - PMC - PubMed
    1. Wegh C.A.M., Geerlings S.Y., Knol J., Roeselers G., Belzer C. Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond. Int. J. Mol. Sci. 2019;20:4673. doi: 10.3390/ijms20194673. - DOI - PMC - PubMed

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