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Review
. 2024 Aug 17;16(8):1311.
doi: 10.3390/v16081311.

Burden of Congenital CMV Infection: A Narrative Review and Implications for Public Health Interventions

Cecilia Liberati  1 , Giulia Sturniolo  1 , Giulia Brigadoi  1 , Silvia Cavinato  2 , Silvia Visentin  3 , Erich Cosmi  3 , Daniele Donà  1 , Osvalda Rampon  1
Affiliations
Review

Burden of Congenital CMV Infection: A Narrative Review and Implications for Public Health Interventions

Cecilia Liberati et al. Viruses. .

Abstract

Cytomegalovirus causes the most common congenital infection worldwide. With most infants asymptomatic at birth, the few affected may present with variable clinical scenarios, from isolated hearing loss to severe neurologic impairment. Public health interventions include all actions at the health system, community, and individual levels that aim at reducing the burden of congenital Cytomegalovirus. This review examines the literature on maternal and neonatal screening programs in light of current evidence for treatment and the development of vaccines against Cytomegalovirus. Potential biases and benefits of these interventions are outlined, with the objective of increasing awareness about the problem and providing readers with data and critical tools to participate in this ongoing debate.

Keywords: CMV awareness; CMV vaccines; cytomegalovirus; maternal screening; neonatal screening.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preventive public measures proposed to reduce the cCMV burden. Adapted from Public Health Interventions (population-based), Minnesota Department of Health [18].
See this image and copyright information in PMC

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