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Review
. 2024 Sep;29(5):e70010.
doi: 10.1111/anec.70010.

Cardiac Arrhythmias in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Mechanistic Insights, Pathophysiology, and Outcomes

Abdulrahman Abouzaid  1 , Khansa Ali  2 , Suniya Jatoi  2 , Mansoor Ahmed  2 , Gulfam Ahmad  2 , Ahsan Nazim  2 , Amin Mehmoodi  3 , Jahanzeb Malik  4
Affiliations
Review

Cardiac Arrhythmias in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Mechanistic Insights, Pathophysiology, and Outcomes

Abdulrahman Abouzaid et al. Ann Noninvasive Electrocardiol. 2024 Sep.

Abstract

Arrhythmias are increasingly recognized as severe complications of precapillary pulmonary hypertension, encompassing pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Despite their significant contribution to symptoms, morbidity, in-hospital mortality, and potentially sudden death in PAH/CTEPH, there remains a lack of comprehensive data on epidemiology, pathophysiology, and outcomes to inform the management of these patients. This review provides an overview of the latest evidence on this subject, spanning from the molecular mechanisms underlying arrhythmias in the hypertrophied or failing right heart to the clinical aspects of epidemiology, diagnosis, and treatment.

Keywords: arrhythmias; chronic thromboembolic pulmonary hypertension; management; pulmonary arterial hypertension; pulmonary hypertension.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
A schematic representation depicting the progression and impact of arrhythmias in pulmonary hypertension (PH).
See this image and copyright information in PMC

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