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Case Reports
. 2024 Jul 29;16(7):e65669.
doi: 10.7759/cureus.65669. eCollection 2024 Jul.

A Case Report and Review of Diagnostic and Therapeutic Challenges of a Malignant Peripheral Nerve Sheath Tumor in the Foot

Khushbu Vaidya  1 , Raju K Shinde  1 , Somya Goel  1 , Kavisha Shah  2
Affiliations
Case Reports

A Case Report and Review of Diagnostic and Therapeutic Challenges of a Malignant Peripheral Nerve Sheath Tumor in the Foot

Khushbu Vaidya et al. Cureus. .

Abstract

Malignant peripheral nerve sheath tumors are rare. It is a soft tissue carcinoma with an aggressive nature, and it is usually associated with a poor prognosis. Common clinical presentations may include local pain, weakness, a growing mass, tingling, and numbness due to the compression of adjacent nerves or tissues, as well as weakness in affected nerves. Radiological assessment tools, such as magnetic resonance imaging and histopathological analysis, can confirm the diagnosis of malignant peripheral nerve sheath tumors. A multidisciplinary approach can manage these tumors with a timely follow-up to improve the outcomes. This is the case report of a 56-year-old female with a painless lesion on her left foot for 15 years, which recently started causing pain and a sticky discharge over the past six months. The patient was later diagnosed with a malignant peripheral nerve sheath tumor on histopathological examination, which was managed by forefoot excision without any complications. The patient recovered well at the three-month follow-up with no new complaints.

Keywords: discoloration of the foot; foot tumors; malignant tumors; nerve sheath tumors; progressive swelling.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. (A-D) Physical presentation of the swelling of the foot
Figure 2
Figure 2. X-ray imaging of the left foot over the dorsal aspect and anteroposterior plane
Figure 3
Figure 3. MRI of the foot (sagittal plane)
MRI: magnetic resonance imaging
Figure 4
Figure 4. MRI of the foot (coronal plane)
MRI: magnetic resonance imaging
Figure 5
Figure 5. MRI of the foot (axial plane)
MRI: magnetic resonance imaging
Figure 6
Figure 6. Image after tumor excision
Figure 7
Figure 7. Histopathological examination of the slide suggestive of malignant peripheral nerve sheath tumor (10x magnification)
Figure 8
Figure 8. Histopathological examination of the slide suggestive of malignant peripheral nerve sheath tumor (40x magnification)
Figure 9
Figure 9. Postsurgery forefoot amputation image
See this image and copyright information in PMC

References

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