Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 5;22(6):473-480.
doi: 10.18502/ijrm.v22i6.16798. eCollection 2024 Jun.

Endometriosis and adverse pregnancy outcomes: A case-control study

Fatemeh Shahmoradi  1 , Ladan Haghighi  1 , Marziyeh Noori  1 , Roya Derakhshan  1   2   3 , Neda Hashemi  1   2 , Samaneh Rokhgireh  1   2
Affiliations

Endometriosis and adverse pregnancy outcomes: A case-control study

Fatemeh Shahmoradi et al. Int J Reprod Biomed. .

Abstract

Background: The association between endometriosis and the outcome of pregnancy is one of the interesting topics. Endometriosis-related pain is alleviated with pregnancy; however, it is known to cause adverse outcomes in pregnancy. The main cause is systemic chronic inflammation caused by higher levels of cytokines, growth factors, and angiogenesis factors.

Objective: This study aimed to clarify the relationship between endometriosis, deep endometriosis, adenomyosis, surgical treatment, and poor maternal consequences.

Materials and methods: In this case-control study, data from 250 women who gave birth in Hazrat Rasoul Akram hospital, Tehran, Iran from February 2015 to December 2019 was extracted from the hospital information system in January 2020. Participants were divided into 2 groups: 125 women with endometriosis and 125 women without endometriosis. We looked at how endometriosis affected mothers and newborn babies. Data on pregnancy, delivery, and newborns of both groups was extracted.

Results: The mean age of participants was 32.74 ± 4.10 and 31.7 ± 5.53 yr in endometriosis and control group, respectively. In terms of pregnancy complications, placenta previa, placenta accreta, placenta abruption, pre-eclampsia, gestational diabetes mellitus, and postpartum hemorrhage remarkably increased in the endometriosis group compared to the control group. Small for gestational age was significantly higher in rectal endometriosis than women without rectal endometriosis (p = 0.03). The neonatal intensive care unit admission rate was notably higher in infants of the endometriosis group compared to controls (40.7% vs. 24.8%, p = 0.009).

Conclusion: Our findings showed women with endometriosis are at a higher risk for important adverse maternal outcomes.

Keywords: Cesarean section; Pre-eclampsia; Pregnancy outcomes; Preterm birth; Small for gestational age.; Endometriosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Assessment of preterm birth predictive factors.
See this image and copyright information in PMC

References

    1. von Theobald P, Cottenet J, Iacobelli S, Quantin C. Epidemiology of endometriosis in France: A large, nation-wide study based on hspital discharge data. BioMed Res Int. 2016;2016:3260952. - PMC - PubMed
    1. Eisenberg VH, Weil C, Chodick G, Shalev V. Epidemiology of endometriosis: A large population-based database study from a healthcare provider with 2 million members. BJOG. 2018;125:55–62. - PubMed
    1. Bhattacharya S, Porter M, Amalraj E, Templeton A, Hamilton M, Lee AJ, et al. The epidemiology of infertility in the North East of Scotland. Hum Reprod. 2009;24:3096–3107. - PubMed
    1. Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D'Hooghe T, De Bie B, et al. ESHRE guideline: Management of women with endometriosis. Hum Reprod. 2014;29:400–412. - PubMed
    1. Kennedy S, Bergqvist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698–2704. - PubMed

LinkOut - more resources