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Review
. 2024 Aug 19;23(8):152.
doi: 10.31083/j.jin2308152.

The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives

Wael Mohamed  1   2 , Mohamed Abdelhalim Eltantawi  3 , Vidhu Agarwal  4 , Sara Bandres-Ciga  5 , Mary B Makarious  5   6 , Yasser Mecheri  7 , Yared Zenebe Zewde  8 , Walaa A Kamel  9 , Bashayer Al-Mubarak  10 , Karem H Alzoubi  11 , Najib Kissani  12 , Badrah S Alghamdi  13 , Samia Ben Sassi  14 ; AA-PD-GC
Affiliations
Free article
Review

The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives

Wael Mohamed et al. J Integr Neurosci. .
Free article

Abstract

Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.

Keywords: AfrAbia; Parkinson's disease; challenges; gaps; genetics; prospects.

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Conflict of interest statement

Wael Mohamed is serving as one of the Guest editors of this journal. We declare that Wael Mohamed had no involvement in the peer review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Gernot Riedel. The authors declare no conflict of interest.

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