Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024:37:513-527.
doi: 10.1007/978-3-031-55529-9_28.

Microglia in Glioma

Stefano Garofalo  1 , Giuseppina D'Alessandro  1 , Cristina Limatola  2
Affiliations
Review

Microglia in Glioma

Stefano Garofalo et al. Adv Neurobiol. 2024.

Abstract

Myeloid cells are fundamental constituents of the brain tumor microenvironment. In this chapter, we describe the state-of-the-art knowledge on the role of microglial cells in the cross-talk with the most common and aggressive brain tumor, glioblastoma. We report in vitro and in vivo studies related to glioblastoma patients and glioma models to outline the symbiotic interactions that microglia develop with tumoral cells, highlighting the heterogeneity of microglial functions in shaping the brain tumor microenvironment.

Keywords: Cold Tumor; Glioblastoma; Glioma-associated microglia/macrophages; Lymphocytes; Tumor Microenvironment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

Bibliography

    1. Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM (2011) Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 14(9):1142–1149. https://doi.org/10.1038/nn.2887 - DOI - PubMed
    1. Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ (2019) Challenges to curing primary brain tumours. Nat Rev Clin Oncol 16(8):509–520. https://doi.org/10.1038/s41571-019-0177-5 - DOI - PubMed - PMC
    1. Alghamri MS, McClellan BL, Avvari RP, Thalla R, Carney S, Hartlage MS, Haase S, Ventosa M, Taher A, Kamran N, Zhang L, Faisal SM, Núñez FJ, Garcia-Fabiani MB, Al-Holou WN, Orringer D, Hervey-Jumper S, Heth J, Patil PG, Eddy K, Merajver SD, Ulintz PJ, Welch J, Gao C, Liu J, Núñez G, Hambardzumyan D, Lowenstein PR, Castro MG (2021) G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy. Sci Adv 7(40):eabh3243. https://doi.org/10.1126/sciadv.abh3243 - DOI - PubMed - PMC
    1. Amankulor NM, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, Margineantu DH, Rao A, Bolouri H, Delrow J, Hockenbery D, Houghton AM, Holland EC (2017) Mutant IDH1 regulates the tumor-associated immune system in gliomas. Genes Dev 31(8):774–786. https://doi.org/10.1101/gad.294991.116 - DOI - PubMed - PMC
    1. Azambuja JH, Ludwig N, Yerneni SS, Braganhol E, Whiteside TL (2020) Arginase-1+ exosomes from reprogrammed macrophages promote glioblastoma progression. Int J Mol Sci 21(11):3990. https://doi.org/10.3390/ijms21113990 - DOI - PubMed - PMC

LinkOut - more resources