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Comment
. 2024 Aug 30;385(6712):930-931.
doi: 10.1126/science.adr7417. Epub 2024 Aug 29.

Micronuclear collapse mechanisms in cancer

Marianna Maddaluno  1   2 , Carmine Settembre  1   2
Affiliations
Comment

Micronuclear collapse mechanisms in cancer

Marianna Maddaluno et al. Science. .

Abstract

Oxidative damage triggers micronuclear membrane rupture and defective repair.

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  • A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
    Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S. Martin S, et al. Science. 2024 Aug 30;385(6712):eadj7446. doi: 10.1126/science.adj7446. Epub 2024 Aug 30. Science. 2024. PMID: 39208097 Free PMC article.

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