2.2 Continous dopaminergic stimulation: concept and evidence
- PMID: 39208181
- Bookshelf ID: NBK604718
2.2 Continous dopaminergic stimulation: concept and evidence
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Sections
- The role of dopaminergic neuronal degeneration in the development of motor complications
- Pre-clinical evidence in support of loss of dopamine storage in the genesis of motor complications with advancing PD
- The role of intermittent L-dopa administration in the development of motor complications
- Central pharmacodynamic changes induced by long-term intermittent L-dopa therapy can be partly reversible
- Support for continuous dopaminergic stimulation
- References
References
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- Ehringer H, Hornykiewicz O. [Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system] Klin Wochenschr. 1960;38:1236–1239. - PubMed
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- Cotzias GC, Papavasiliou PS, Gellene R. Modification of Parkinsonism–chronic treatment with L-dopa. N Engl J Med. 1969;280:337–345. - PubMed
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- Barbeau A, Gillo-Joffroy L, Mars H. Treatment of Parkinson's disease with levodopa and Ro 4-4602. Clin Pharmacol Ther. 1971;12:353–359. - PubMed
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- Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord. 2001;16:448–458. - PubMed
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