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. 2024 Nov 15;230(5):e1077-e1081.
doi: 10.1093/infdis/jiae436.

Impact of Human Leukocyte Antigen Allele-Killer Cell Immunoglobulin-like Receptor Partners on Sexually Transmitted Human Immunodeficiency Virus Type 1 Infection

Carmen Serrano-Rísquez  1 , Mohamed Omar  2 , Norma Rallón  3 , José Miguel Benito  4 , Amparo Gómez-Vidal  2 , Francisco J Márquez  1 , Martina Alján  1 , Antonio Rivero-Juárez  5   6 , Ignacio Pérez-Valero  5   6 , Antonio Rivero  5   6 , Faruk Sinangil  7 , Irma Saulle  8 , Mara Biasin  8 , Mario Clerici  9   10 , Donald Forthal  11 , Maria Eugenia Saéz  12 , Antonio Caruz  1
Affiliations

Impact of Human Leukocyte Antigen Allele-Killer Cell Immunoglobulin-like Receptor Partners on Sexually Transmitted Human Immunodeficiency Virus Type 1 Infection

Carmen Serrano-Rísquez et al. J Infect Dis. .

Abstract

Human leukocyte antigen (HLA) class I/killer cell immunoglobulin-like receptor (KIR) genotypes influence human immunodeficiency virus type 1 (HIV-1) disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral versus sexual-may influence this association. We conducted a genome-wide association study in a population of people with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.

Keywords: GWAS; HESN; HIV-1; HLA; KIR.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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