doi: 10.1053/j.gastro.2024.08.021.
Epub 2024 Aug 30.
Development and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study
Collaborators,
Affiliations
Collaborators
-
Crohn's and Colitis Canada-Genetic, Environmental, Microbial (CCC-GEM) Project Research Consortium:
Sun-Ho Lee 5 , Williams Turpin 5 , Osvaldo Espin-Garcia 2 , Wei Xu 3 , Haim Leibovitzh 5 , Mingyue Xue 6 , Juan Antonio Raygoza Garay 5 , Lucía Graña-Miraglia 7 , Michelle I Smith 6 , Ashleigh Goethel 6 , Karen L Madsen 8 , Irit Avni-Biron 9 , Iris Dotan 9 , Batia Weiss 10 , Remo Panaccione 11 , Hien Huynh 12 , Kevan Jacobson 13 , Guy Aumais 14 , David Mack 15 , Anne M Griffiths 16 , A Hillary Steinhart 5 , Mark S Silverberg 5 , Dan Turner 17 , Charles N Bernstein 18 , Brian G Feagan 19 , Paul Moayyedi 20 , Andrew Paterson 21 , David S Guttman 7 , Maria Abreu 22 , Paul Beck 11 , Leo Dieleman 8 , Gilaad Kaplan 11 , Denis O Krause 18 , John Marshall 10 , Mark Ropeleski 23 , Ernest Seidman 24 , Scott Snapper 25 , Andy Stadnyk 26 , Michael Surette 10 , Thomas Walters 16 , Bruce Vallance 13 , Alain Bitton 24 , Maria Cino 27 , Jeff Critch 28 , Lee Denson 29 , Colette Deslandres 30 , Wael El-Matary 18 , Hans Herfarth 31 , Peter Higgins 32 , Jeff Hyams 33 , Jerry McGrath 34 , Anthony Otley 35 , Kenneth Croitoru 5
Affiliations
- 1 Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 2 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
- 3 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
- 4 Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: Ken.Croitoru@sinaihealth.ca.
- 5 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 6 Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 7 Department of Cell & Systems Biology, and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario.
- 8 University of Alberta, Edmonton, Alberta, Canada.
- 9 Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel, Faculty of Medicine, Tel Aviv University, Israel.
- 10 Pediatric Gastroenterology Unit, Sheba Medical Center, Tel-Hashomer, Israel.
- 11 Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada.
- 12 Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
- 13 Canadian Gastro-Intestinal Epidemiology Consortium, Canada; British Columbia Children's Hospital, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
- 14 Hôpital Maisonneuve-Rosemont, Department of Medicine, University of Montreal, Montreal, Quebec, Canada.
- 15 Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada.
- 16 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 17 The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
- 18 University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Winnipeg, Canada.
- 19 Departments of Medicine, Epidemiology, and Biostatistics University of Western Ontario, London, Ontario, Canada.
- 20 Department of Medicine, McMaster University, Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.
- 21 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada; Genetics and Genome Biology, The Hospital for Sick Children Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 22 Division of Gastroenterology, Crohn's and Colitis Center, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida.
- 23 Department of Medicine, Queens University, Kingston, Ontario, Canada.
- 24 Division of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada.
- 25 Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
- 26 Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
- 27 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
- 28 Department of Pediatrics, Memorial University, St. John's, NL, Canada.
- 29 Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
- 30 Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
- 31 Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
- 32 Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
- 33 Connecticut Children's Medical Center Hartford, Connecticut.
- 34 Division of Gastroenterology, Memorial University of Newfoundland, St. John's, NL, Canada.
- 35 Department of Pediatrics, IWK Health, Dalhousie University, Halifax, Nova Scotia, Canada.
- PMID: 39209122
- DOI: 10.1053/j.gastro.2024.08.021
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Development and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study
Sun-Ho Lee et al.
Gastroenterology.
2025 Jan.
Free article
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doi: 10.1053/j.gastro.2024.08.021.
Epub 2024 Aug 30.
Authors
Collaborators
-
Crohn's and Colitis Canada-Genetic, Environmental, Microbial (CCC-GEM) Project Research Consortium:
Sun-Ho Lee 5 , Williams Turpin 5 , Osvaldo Espin-Garcia 2 , Wei Xu 3 , Haim Leibovitzh 5 , Mingyue Xue 6 , Juan Antonio Raygoza Garay 5 , Lucía Graña-Miraglia 7 , Michelle I Smith 6 , Ashleigh Goethel 6 , Karen L Madsen 8 , Irit Avni-Biron 9 , Iris Dotan 9 , Batia Weiss 10 , Remo Panaccione 11 , Hien Huynh 12 , Kevan Jacobson 13 , Guy Aumais 14 , David Mack 15 , Anne M Griffiths 16 , A Hillary Steinhart 5 , Mark S Silverberg 5 , Dan Turner 17 , Charles N Bernstein 18 , Brian G Feagan 19 , Paul Moayyedi 20 , Andrew Paterson 21 , David S Guttman 7 , Maria Abreu 22 , Paul Beck 11 , Leo Dieleman 8 , Gilaad Kaplan 11 , Denis O Krause 18 , John Marshall 10 , Mark Ropeleski 23 , Ernest Seidman 24 , Scott Snapper 25 , Andy Stadnyk 26 , Michael Surette 10 , Thomas Walters 16 , Bruce Vallance 13 , Alain Bitton 24 , Maria Cino 27 , Jeff Critch 28 , Lee Denson 29 , Colette Deslandres 30 , Wael El-Matary 18 , Hans Herfarth 31 , Peter Higgins 32 , Jeff Hyams 33 , Jerry McGrath 34 , Anthony Otley 35 , Kenneth Croitoru 5
Affiliations
- 1 Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 2 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
- 3 Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Biostatistics Department, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
- 4 Division of Gastroenterology and Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: Ken.Croitoru@sinaihealth.ca.
- 5 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 6 Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 7 Department of Cell & Systems Biology, and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario.
- 8 University of Alberta, Edmonton, Alberta, Canada.
- 9 Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel, Faculty of Medicine, Tel Aviv University, Israel.
- 10 Pediatric Gastroenterology Unit, Sheba Medical Center, Tel-Hashomer, Israel.
- 11 Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada.
- 12 Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
- 13 Canadian Gastro-Intestinal Epidemiology Consortium, Canada; British Columbia Children's Hospital, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
- 14 Hôpital Maisonneuve-Rosemont, Department of Medicine, University of Montreal, Montreal, Quebec, Canada.
- 15 Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada.
- 16 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 17 The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
- 18 University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre and, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Winnipeg, Canada.
- 19 Departments of Medicine, Epidemiology, and Biostatistics University of Western Ontario, London, Ontario, Canada.
- 20 Department of Medicine, McMaster University, Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.
- 21 Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada; Genetics and Genome Biology, The Hospital for Sick Children Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 22 Division of Gastroenterology, Crohn's and Colitis Center, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida.
- 23 Department of Medicine, Queens University, Kingston, Ontario, Canada.
- 24 Division of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada.
- 25 Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
- 26 Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
- 27 Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
- 28 Department of Pediatrics, Memorial University, St. John's, NL, Canada.
- 29 Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
- 30 Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
- 31 Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
- 32 Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
- 33 Connecticut Children's Medical Center Hartford, Connecticut.
- 34 Division of Gastroenterology, Memorial University of Newfoundland, St. John's, NL, Canada.
- 35 Department of Pediatrics, IWK Health, Dalhousie University, Halifax, Nova Scotia, Canada.
- PMID: 39209122
- DOI: 10.1053/j.gastro.2024.08.021
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