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Review
. 2024 Jun 30;35(2):220-233.
doi: 10.31138/mjr.240224.cap. eCollection 2024 Jun.

Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases

Jan René Nkeck  1   2 , Ange Larissa Tchuisseu-Kwangoua  1   3 , Adeline Pelda  1   2   4 , Wilson Chia Tamko  1   2   4 , Saquinatou Hamadjoda  1   2   4 , Doris Bibi Essama  2 , Baudelaire Fojo  1   2   4 , Moustapha Niasse  5 , Saïdou Diallo  5 , Madeleine Ngandeu-Singwé  1   2   4
Affiliations
Review

Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases

Jan René Nkeck et al. Mediterr J Rheumatol. .

Abstract

Advances in knowledge of the microbiome and its relationship with the immune system have led to a better understanding of the pathogenesis of chronic inflammatory rheumatic diseases (CIRD). Indeed, the microbiome dysbiosis now occupies a particular place with implications for the determinism and clinical expression of CIRD, as well as the therapeutic response of affected patients. Several approaches exist to limit the impact of the microbiome during CIRD. This review aimed to present current strategies to prevent or reverse microbiome dysbiosis based on existing knowledge, in order to provide practical information to healthcare professionals treating patients suffering from CIRD.

Keywords: chronic inflammatory rheumatic diseases; dysbiosis; microbiome; prevention; sub-Saharan Africa; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1:
Figure 1:
Chronic inflammatory rheumatic diseases and mostly associated dysbiosis. AS: ankylosing spondylarthritis; IMM: idiopathic inflammatory myositis; PsA: psoriatic arthritis; RA: rheumatoid arthritis; ReA: reactive arthritis; SLE: systemic lupus erythematosus; SS: Sjögren’s syndrome; SSc: systemic sclerosis; Vasc: vasculitis.
Figure 2:
Figure 2:
Strategies for preventing and restoring dysbiosis in the microbiome.
See this image and copyright information in PMC

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