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Case Reports
. 2024 Jan 29;35(2):305-308.
doi: 10.31138/mjr.260123.ina. eCollection 2024 Jun.

Two Concomitant Rare Extraglandular Manifestations of Primary Sjögren's Syndrome: IgA Nephropathy and Autoimmune Hepatitis

Rashmi Roongta  1 , Sonali Dey  1 , Sumantro Mondal  1 , Alakendu Ghosh  1
Affiliations
Case Reports

Two Concomitant Rare Extraglandular Manifestations of Primary Sjögren's Syndrome: IgA Nephropathy and Autoimmune Hepatitis

Rashmi Roongta et al. Mediterr J Rheumatol. .

Abstract

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease and can rarely present with multiple extraglandular manifestations. Here we report a case of pSS with concomitant IgA nephropathy and autoimmune hepatitis as the initial manifestations. She presented with polyarthralgia, sicca symptoms and persistent fatigue but was asymptomatic for renal and liver involvement. Autoimmune diseases can have overlapping clinical features and occasionally, manifest nonspecific symptoms leading to delay in diagnosis. It is therefore imperative to thoroughly evaluate any patient of pSS for early recognition of the diverse extraglandular features and initiate prompt treatment to improve outcome.

Keywords: IgA nephropathy; Sjögren’s syndrome; autoimmune; glomerulonephritis; hepatitis.

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Conflict of interest statement

None of the authors have any potential conflicts of interest to disclose.

Figures

Figure 1A–B.
Figure 1A–B.
Renal biopsy showed mesangial hypercellularity in all viable glomeruli and immunofluorescence demonstrated mesangial deposits of IgA (2+).
See this image and copyright information in PMC

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