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Case Reports
. 2024 Apr 17;6(8):973-977.
doi: 10.1016/j.cjco.2024.04.004. eCollection 2024 Aug.

Multimodality Imaging of Acute Myocarditis in Cytokine Release Syndrome (CRS) Following CAR-T Therapy

Janane Maheswaran  1 , Moezedin Javad Rafiee  2 , Sydney Cordes  3 , Benedicte Lefebvre  4 , Michael Chetrit  1   2
Affiliations
Case Reports

Multimodality Imaging of Acute Myocarditis in Cytokine Release Syndrome (CRS) Following CAR-T Therapy

Janane Maheswaran et al. CJC Open. .
No abstract available

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Figures

Figure 1
Figure 1
Transthoracic echocardiogram images in patient with chimeric antigen receptor CAR T-cell–induced myocarditis. (A) Parasternal long-axis view; (B) subcostal view showing no significant pericardial effusion; and (C) left ventricular strain demonstrating overall low global strain of –11.4%, and regional abnormalities of the basal to mid anterior and anteroseptum (ANT_SEPT). ANT, anterior; GLPS, Global Longitudinal Peak Strain; HR, heart rate; INF, inferior; LAT, lateral; LAX, POST, posterior; SEPT, septal.
Figure 2
Figure 2
(A) T1 mapping of the short-axis mid-ventricular slice of the left ventricle (LV) demonstrating diffusely prolonged T1 relaxation time (red) with very minimal normal relaxivity along the lateral wall (green). Increased T1 values in noted globally (arrow). (B) T2 mapping of the short-axis mid-ventricular slice of the LV demonstrating diffusely prolonged T2 decay (blue) with very minimal normal decay in the mid-septum and anterolateral walls (yellow). Increased T2 values globally sparing the mid septum (arrows). The combination of (A) and (B) is indicative of inflammation. (C) T2 Short Tau Inversion Recovery (STIR) sequence of the short-axis mid ventricular slice of the LV, demonstrating increased signal compared to the skeletal muscle signal (blue), reflecting the diffuse edema noted on the (B) T2 map. (D) Evidence of nonischemic pattern of late gadolinium enhancement manifesting as linear subepicardial enhancement of the mid entire lateral wall in short-axis view (thin arrows) on late gadolinium enhancement sequence associated with enhancement of the adjacent pericardium.
See this image and copyright information in PMC

References

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