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Review
. 2024 Aug 31;50(4):177-188.
doi: 10.5125/jkaoms.2024.50.4.177.

The role of endoplasmic reticulum stress in the pathogenesis of oral diseases

Kezia Rachellea Mustakim  1 , Mi Young Eo  1 , Soung Min Kim  1
Affiliations
Review

The role of endoplasmic reticulum stress in the pathogenesis of oral diseases

Kezia Rachellea Mustakim et al. J Korean Assoc Oral Maxillofac Surg. .

Abstract

The endoplasmic reticulum (ER) is crucial for protein synthesis, transport, and folding, as well as calcium storage, lipid and steroid synthesis, and carbohydrate metabolism. Endoplasmic reticulum stress (ERS) occurs when misfolded or unfolded proteins accumulate in the ER lumen due to increased protein secretion or impaired folding. While the role of ERS in disease pathogenesis has been widely studied, most research has focused on extraoral diseases, leaving the role of ERS in intraoral diseases unclear. This review examines the role of ERS in oral diseases and oral fibrosis pathogenesis. A systematic search of literature through July 2023 was conducted in the MEDLINE database (via PubMed) using specific terms related to ERS, oral diseases, and fibrosis. The findings were summarized in both table and narrative form. Emerging evidence indicates that ERS significantly contributes to the pathogenesis of oral diseases and fibrosis. ERS-induced dysregulation of protein folding and the unfolded protein response can lead to cellular dysfunction and inflammation in oral tissues. Understanding the relationship between ERS and oral disease pathogenesis could offer new therapeutic targets for managing oral health and fibrosis-related complications.

Keywords: Endoplasmic reticulum stress; Fibrosis; Oral pathology; Pathogenesis-related proteins; Unfolded protein response.

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Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Identification of relevant literature.
See this image and copyright information in PMC

References

    1. Schwarz DS, Blower MD. The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci. 2016;73:79–94. doi: 10.1007/s00018-015-2052-6. https://doi.org/10.1007/s00018-015-2052-6. - DOI - PMC - PubMed
    1. Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, Leuzzi B, et al. Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. FEBS J. 2019;286:241–78. doi: 10.1111/febs.14608. https://doi.org/10.1111/febs.14608. - DOI - PMC - PubMed
    1. Hetz C, Zhang K, Kaufman RJ. Mechanisms, regulation and functions of the unfolded protein response. Nat Rev Mol Cell Biol. 2020;21:421–38. doi: 10.1038/s41580-020-0250-z. https://doi.org/10.1038/s41580-020-0250-z. - DOI - PMC - PubMed
    1. Marciniak SJ. Endoplasmic reticulum stress: a key player in human disease. FEBS J. 2019;286:228–31. doi: 10.1111/febs.14740. https://doi.org/10.1111/febs.14740. - DOI - PubMed
    1. Kropski JA, Blackwell TS. Endoplasmic reticulum stress in the pathogenesis of fibrotic disease. J Clin Invest. 2018;128:64–73. doi: 10.1172/JCI93560. https://doi.org/10.1172/JCI93560. - DOI - PMC - PubMed