Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 30;28(9):506.
doi: 10.1007/s00784-024-05893-y.

Association of periodontitis with cardiometabolic and haemostatic parameters

Hester Groenewegen #  1 , Jaime F Borjas-Howard #  2 , Karina Meijer  2 , Ton Lisman  3 , Arjan Vissink  4 , Fred K L Spijkervet  4 , Willem Nesse  5 , Vladimir Y I G V Tichelaar  2
Affiliations

Association of periodontitis with cardiometabolic and haemostatic parameters

Hester Groenewegen et al. Clin Oral Investig. .

Abstract

Objective: To investigate the association between periodontitis and cardiometabolic and haemostatic parameters.

Materials and methods: Between 2014 and 2019, 54 individuals needing full mouth extraction, and 50 control individuals, were recruited for a combined cross-sectional (individuals versus controls) and longitudinal (individuals before and after extraction) study. Periodontitis severity was measured using the periodontal inflamed surface area (PISA). Blood was drawn to measure the haemostatic (Factor VIII, von Willebrand factor [VWF], endogenous thrombin potential, d-dimer, clot lysis time) and cardiovascular risk (C-reactive protein [CRP], lipid profile) parameters, prior to and 12 weeks post-extraction. The results were analysed group-wise.

Results: The mean VWF and CRP levels were higher and the high-density lipoprotein levels were lower in the individuals prior to extraction compared to the controls. The VWF was significantly correlated with the PISA (a 21% unit increase in VWF per 1000 mm2 increase in PISA, 95%CI: 6-36%, p = 0.01). The other analyses were comparable between the individuals and controls, and did not change in the individuals after the extraction.

Conclusion: VWF levels are associated with periodontitis severity; they do not improve after full-mouth extraction. Severe periodontitis in control individuals does not induce substantial changes in their haemostatic or inflammatory systems.

Clinical relevance: Treatment of periodontitis has been shown to improve the cardiometabolic blood profile of patients with established cardiometabolic disease. However, whether periodontitis treatment improves cardiometabolic and haemostatic profiles in people without cardiometabolic disease is uncertain.

Keywords: Cardiovascular diseases; Inflammation; Periodontitis; Tooth extraction; Venous thromboembolism.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart depicting recruitment of individuals undergoing full mouth extraction
See this image and copyright information in PMC

References

    1. Jiménez D, García-Sanchez A, Rali P et al (2021) Incidence of VTE and bleeding among hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis. Chest 159(3):1182–1196 - PMC - PubMed
    1. Alves C, Penedones A, Mendes D, Marques FB (2022) Risk of cardiovascular and venous thromboembolic events associated with janus kinase inhibitors in rheumatoid arthritis: a systematic review and network meta-analysis. J Clin Rheumatol 28(2):69–76 - PubMed
    1. Dommisch H, Kebschull M (2014) Chronic periodontitis. In: Newman MG, Carranza FA, Takei H, Klokkevold PR (eds) Carranza’s clinical periodontology, 12th edn. Elsevier health sciences, p 309
    1. Paraskevas S, Huizinga JD, Loos BG (2008) A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 35(4):277–290 - PubMed
    1. Ohki T, Itabashi Y, Kohno T et al (2012) Detection of periodontal bacteria in thrombi of patients with acute myocardial infarction by polymerase chain reaction. Am Heart J 163(2):164–167 - PubMed

MeSH terms

LinkOut - more resources