Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2024;37(6):1673-1683.
doi: 10.3233/BMR-240106.

Clinical trial of arthroscopic debridement combined with functional exercise in the treatment of advanced knee osteoarthritis: A retrospective observational study

Shiming Huang, Qiang Wang, Daohua Chen, Peng Zhan, Dongfeng Chen
Observational Study

Clinical trial of arthroscopic debridement combined with functional exercise in the treatment of advanced knee osteoarthritis: A retrospective observational study

Shiming Huang et al. J Back Musculoskelet Rehabil. 2024.

Abstract

Background: Advanced knee osteoarthritis (KOA) impacts both knees, resulting in pain, deformity, and substantial restrictions in joint mobility.

Objective: This study aims to examine the effectiveness of combining arthroscopic debridement with functional exercise in treating advanced KOA.

Methods: A total of 296 patients diagnosed with advanced KOA were divided into two groups: the observation group (n= 152) received arthroscopic debridement combined with functional exercise, while the control group (n= 144) underwent arthroscopic debridement only. The study compared and observed the outcomes between the two groups.

Results: There were no significant differences in knee joint function, inflammation level, and oxidative stress between the two groups before treatment (P> 0.05). Following treatment for six months, the observation group exhibited significantly lower visual analog scale (VAS) score, tissue inhibitors of metalloproteinase-1 (TIMP-1), tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), matrix metalloproteinase-3 (MMP-3), and malondialdehyde (MDA) levels compared to the control group (P< 0.05). Meanwhile, the observation group showed significantly higher levels of Lysholm score, hospital for special surgery (HSS) score, range of motion (ROM) of knee, peak torque (PT) and total work (TW) for knee extension and flexion, superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione (GSH) compared to the control group (P< 0.05). Besides, the effective treatment rate in the observation group was notably higher than that in the control group (80.92% vs. 69.44%, P< 0.05).

Conclusion: The combination of arthroscopic debridement with functional exercise is an effective treatment for advanced KOA. This approach not only enhances the function and strength of knee joint and reduces inflammatory response but also boosts the body's antioxidant capacity. The treatment exhibits encouraging outcomes and warrants broad implementation.

Keywords: Advanced knee osteoarthritis; Arthroscopic debridement; Functional exercise; Retrospective observation; Therapeutic effects.

PubMed Disclaimer

Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flowchart of the study design.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Geng R, Li J, Yu C, Zhang C, Chen F, Chen J, Ni H, Wang J, Kang K, Wei Z, Xu Y, Jin T. Knee osteoarthritis: Current status and research progress in treatment (Review). Exp Ther Med. 2023; 26(4): 481. - PMC - PubMed
    1. Kao MH, Tsai YF. Illness experiences in middle-aged adults with early-stage knee osteoarthritis: findings from a qualitative study. J Adv Nurs. 2014; 70(7): 1564-1572. - PubMed
    1. Sun X, Zhen X, Hu X, Li Y, Gu S, Gu Y, Dong H. Osteoarthritis in the middle-aged and elderly in China: prevalence and influencing factors. Int J Environ Res Public Health. 2019; 16(23): 4701. - PMC - PubMed
    1. Quatman CE, Hettrich CM, Schmitt LC, Spindler KP. The clinical utility and diagnostic performance of magnetic resonance imaging for identification of early and advanced knee osteoarthritis: a systematic review. Am J Sports Med. 2011. Jul; 39(7): 1557-1568. - PMC - PubMed
    1. Wang L, Wang Q, Li Q, Song F. A comparative study of total knee arthroplasty and unicondylar knee arthroplasty in the treatment of knee osteoarthritis. Contrast Media Mol Imaging. 2022; 2022: 7795801. - PMC - PubMed

Publication types

LinkOut - more resources