A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY)

Nicholas Geremia¹, Gianfranco Sanson², Luigi Principe³, Roberta Maria Antonello⁴, Verena Zerbato⁵, Roberto Luzzati⁶; ITANAEROBY study group; Stefano Di Bella²⁷

Collaborators, Affiliations

Collaborators

ITANAEROBY study group:
Alberto Enrico Maraolo⁷, Daniele Roberto Giacobbe⁸, Chiara Sepulcri⁸, Simone Ambretti⁹, Richard Aschbacher¹⁰, Laura Bartolini¹¹, Mariano Bernardo¹², Alessandra Bielli¹³, Marina Busetti¹⁴, Davide Carcione¹⁵, Giulio Camarlinghi¹⁶, Edoardo Carretto¹⁷, Tiziana Cassetti¹⁸, Chiara Chilleri¹¹, Francesco Giuseppe De Rosa¹⁹, Saveria Dodaro²⁰, Raffaele Gargiulo¹⁸, Francesca Greco²⁰, Anna Knezevich¹⁶, Jari Intra¹⁵, Tommaso Lupia¹⁹, Erika Concialdi²¹, Gabriele Bianco²², Francesco Luzzaro²³, Carola Mauri²³, Gianluca Morroni²⁴, Adriana Mosca²⁵, Elisabetta Pagani¹⁰, Eva Maria Parisio¹⁶, Claudio Ucciferri²⁶, Chiara Vismara¹³

Affiliations

¹ Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale "Dell'Angelo", 30174, Venice, Italy; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Civile "S.S. Giovanni e Paolo", 30122, Venice, Italy. Electronic address: nich.geremia@gmail.com.
² Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127, Trieste, Italy.
³ Microbiology and Virology Unit, Great Metropolitan Hospital "Bianchi-Melacrino-Morelli", 89128, Reggio Calabria, Italy. Electronic address: luigi.principe@gmail.com.
⁴ Department of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy. Electronic address: rma.roby@gmail.com.
⁵ Infectious Diseases Unit, Trieste University Hospital, 34128, Trieste, Italy. Electronic address: verena.zerbato@gmail.com.
⁶ Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127, Trieste, Italy. Electronic address: roberto.luzzati@asugi.sanita.fvg.it.
⁷ First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy.
⁸ San Martino Polyclinic Hospital IRCCS, Genoa, Italy; Department of Health Sciences, University of Genoa, Genoa, Italy.
⁹ e University Hospital of Bologna-Policlinico Sant'Orsola-Malpighi, Microbiology and Virology Unit, Bologna, Italy.
¹⁰ Laboratory of Microbiology and Virology, Provincial Hospital of Bolzano (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, Italy.
¹¹ Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.
¹² Microbiology Unit, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.
¹³ Clinical Pathology and Microbiology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
¹⁴ Microbiology and Virology Unit, University Hospital of Trieste, Trieste, Italy.
¹⁵ Department of Laboratory Medicine, University of Milano-Bicocca, ASST-Brianza, Desio Hospital, Desio, Italy.
¹⁶ Clinical Pathology and Microbiology Unit, San Luca Hospital, Lucca, Italy.
¹⁷ Clinical Microbiology Laboratory, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
¹⁸ Clinical Microbiology and Virology Unit, AOU Policlinico, Modena, Italy.
¹⁹ Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy; Unit of Infectious Diseases, Cardinal Massaia Hospital, Asti, Italy.
²⁰ Microbiology and Virology Unit, "Annunziata" Hospital of Cosenza, Cosenza, Italy.
²¹ Microbiology Unit, Cardinal Massaia Hospital, Asti, Italy.
²² Microbiology and Virology Unit, Citta della Salute e della Scienza di Torino, University of Turin, Italy.
²³ Clinical Microbiology and Virology Unit, "A. Manzoni" Hospital, Lecco, Italy.
²⁴ Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
²⁵ Interdisciplinary Department of Medicine (DIM), University of Bari "Aldo Moro", Policlinico, Bari, Italy.
²⁶ Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
²⁷ Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127, Trieste, Italy. Electronic address: stefano932@gmail.com.

PMID: 39214165
DOI: 10.1016/j.anaerobe.2024.102901

Observational Study

A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY)

Nicholas Geremia et al. Anaerobe. 2024 Dec.

. 2024 Dec:90:102901.

doi: 10.1016/j.anaerobe.2024.102901. Epub 2024 Aug 28.

Authors

Nicholas Geremia¹, Gianfranco Sanson², Luigi Principe³, Roberta Maria Antonello⁴, Verena Zerbato⁵, Roberto Luzzati⁶; ITANAEROBY study group; Stefano Di Bella²⁷

Collaborators

ITANAEROBY study group:
Alberto Enrico Maraolo⁷, Daniele Roberto Giacobbe⁸, Chiara Sepulcri⁸, Simone Ambretti⁹, Richard Aschbacher¹⁰, Laura Bartolini¹¹, Mariano Bernardo¹², Alessandra Bielli¹³, Marina Busetti¹⁴, Davide Carcione¹⁵, Giulio Camarlinghi¹⁶, Edoardo Carretto¹⁷, Tiziana Cassetti¹⁸, Chiara Chilleri¹¹, Francesco Giuseppe De Rosa¹⁹, Saveria Dodaro²⁰, Raffaele Gargiulo¹⁸, Francesca Greco²⁰, Anna Knezevich¹⁶, Jari Intra¹⁵, Tommaso Lupia¹⁹, Erika Concialdi²¹, Gabriele Bianco²², Francesco Luzzaro²³, Carola Mauri²³, Gianluca Morroni²⁴, Adriana Mosca²⁵, Elisabetta Pagani¹⁰, Eva Maria Parisio¹⁶, Claudio Ucciferri²⁶, Chiara Vismara¹³

Affiliations

¹ Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale "Dell'Angelo", 30174, Venice, Italy; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale Civile "S.S. Giovanni e Paolo", 30122, Venice, Italy. Electronic address: nich.geremia@gmail.com.
² Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127, Trieste, Italy.
³ Microbiology and Virology Unit, Great Metropolitan Hospital "Bianchi-Melacrino-Morelli", 89128, Reggio Calabria, Italy. Electronic address: luigi.principe@gmail.com.
⁴ Department of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy. Electronic address: rma.roby@gmail.com.
⁵ Infectious Diseases Unit, Trieste University Hospital, 34128, Trieste, Italy. Electronic address: verena.zerbato@gmail.com.
⁶ Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127, Trieste, Italy. Electronic address: roberto.luzzati@asugi.sanita.fvg.it.
⁷ First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy.
⁸ San Martino Polyclinic Hospital IRCCS, Genoa, Italy; Department of Health Sciences, University of Genoa, Genoa, Italy.
⁹ e University Hospital of Bologna-Policlinico Sant'Orsola-Malpighi, Microbiology and Virology Unit, Bologna, Italy.
¹⁰ Laboratory of Microbiology and Virology, Provincial Hospital of Bolzano (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, Italy.
¹¹ Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.
¹² Microbiology Unit, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.
¹³ Clinical Pathology and Microbiology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
¹⁴ Microbiology and Virology Unit, University Hospital of Trieste, Trieste, Italy.
¹⁵ Department of Laboratory Medicine, University of Milano-Bicocca, ASST-Brianza, Desio Hospital, Desio, Italy.
¹⁶ Clinical Pathology and Microbiology Unit, San Luca Hospital, Lucca, Italy.
¹⁷ Clinical Microbiology Laboratory, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
¹⁸ Clinical Microbiology and Virology Unit, AOU Policlinico, Modena, Italy.
¹⁹ Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy; Unit of Infectious Diseases, Cardinal Massaia Hospital, Asti, Italy.
²⁰ Microbiology and Virology Unit, "Annunziata" Hospital of Cosenza, Cosenza, Italy.
²¹ Microbiology Unit, Cardinal Massaia Hospital, Asti, Italy.
²² Microbiology and Virology Unit, Citta della Salute e della Scienza di Torino, University of Turin, Italy.
²³ Clinical Microbiology and Virology Unit, "A. Manzoni" Hospital, Lecco, Italy.
²⁴ Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
²⁵ Interdisciplinary Department of Medicine (DIM), University of Bari "Aldo Moro", Policlinico, Bari, Italy.
²⁶ Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
²⁷ Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, 34127, Trieste, Italy. Electronic address: stefano932@gmail.com.

PMID: 39214165
DOI: 10.1016/j.anaerobe.2024.102901

Abstract

Clostridium perfingens bloodstream infections (BSIs) can be associated with high mortality rates. We performed a subanalysis of all C. perfringens BSIs enrolled during a multicentric retrospective observational study (ITANAEROBY). Data were collected from January 2016 to December 2020. C. perfringens BSIs were 134 (134/1960, 6.8 %). The highest resistance rate was observed for clindamycin (26/120, 21.6 %), penicillin (11/71, 15.4 %) and metronidazole (14/131, 10.7 %). In conclusion, C. perfringens reduced susceptibility phenotype to first-line therapy.

Keywords: Anaerobes; Antibiotic therapy; Bloodstream infections; Clostridium perfringens.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY)

Collaborators

Affiliations

A subanalysis of Clostridium perfringens bloodstream infections from a 5-year retrospective nationwide survey (ITANAEROBY)

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical