Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Oct;34(10):3888-3896.
doi: 10.1007/s11695-024-07486-w. Epub 2024 Aug 31.

Role of GLP1-RA in Optimizing Weight Loss Post-Bariatric Surgery: A Systematic Review and Meta-Analysis

Mable Pereira  1 , Shenelle Menezes  2 , Ancy Jenil Franco  3 , Patricia Marcolin  4 , Mark Tomera  5
Affiliations
Meta-Analysis

Role of GLP1-RA in Optimizing Weight Loss Post-Bariatric Surgery: A Systematic Review and Meta-Analysis

Mable Pereira et al. Obes Surg. 2024 Oct.

Abstract

Bariatric surgery is a widely used intervention for significant weight loss, yet some patients face challenges with insufficient weight loss or weight regain post-surgery. To address this issue, adjunctive treatments like glucagon-like peptide-1 receptor agonists (GLP1-RAs) are being explored for their potential to enhance weight loss outcomes. This meta-analysis was conducted to evaluate the effectiveness of GLP1-RAs in improving weight loss after bariatric surgery compared to a placebo. By systematically reviewing and analyzing data from three randomized controlled trials (RCTs) involving 130 patients, we found that GLP1-RA therapy, particularly liraglutide (1.8-3 mg), significantly reduced mean BMI and body weight percentage at six months. Future studies should explore newer GLP1-RAs with weekly dosing and include longer follow-up periods to assess the durability of these outcomes.

Keywords: Bariatric surgery; GLP1-RAs; Metabolic surgery; Obesity; Weight regain.

PubMed Disclaimer

References

    1. World Health Organization (WHO) Obesity and Overweight: Fact Sheet. 2022. Retrieved from https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight . Accessed 10 Mar 2024.
    1. Noria SF, Shelby RD, Atkins KD, et al. Weight Regain After Bariatric Surgery: Scope of the Problem, Causes, Prevention, and Treatment. Curr Diab Rep. 2023;23:31–42. https://doi.org/10.1007/s11892-023-01498-z . - DOI - PubMed
    1. Imam A, Alim H, Binhussein M, et al. Weight Loss Effect of GLP-1 RAs With Endoscopic Bariatric Therapy and Bariatric Surgeries. J Endocr Soc. 2023;7(12):bvad129. https://doi.org/10.1210/jendso/bvad129 . - DOI - PubMed
    1. Page MJ et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;n71. https://doi.org/10.1136/bmj.n71
    1. Cumpston M, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019;10:142.

Substances