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Practice Guideline
. 2024 Nov;26(11):2771-2782.
doi: 10.1007/s12094-024-03604-3. Epub 2024 Aug 31.

SEOM-GEICO Clinical Guidelines on cervical cancer (2023)

Luis Manso  1 , Avinash Ramchandani-Vaswani  2 , Ignacio Romero  3 , Luisa Sánchez-Lorenzo  4 , María José Bermejo-Pérez  5 , Purificación Estévez-García  6 , Lorena Fariña-Madrid  7 , Yolanda García García  8 , Marta Gil-Martin  9 , María Quindós  10
Affiliations
Practice Guideline

SEOM-GEICO Clinical Guidelines on cervical cancer (2023)

Luis Manso et al. Clin Transl Oncol. 2024 Nov.

Abstract

Cervical cancer (CC) is the fourth most common cancer and the fourth leading cause of mortality in women worldwide. It is strongly associated with high-risk human papillomavirus infection. High-income countries that have implemented human papillomavirus (HPV) vaccination and screening programs have seen dramatic reductions in CC incidence, while developing countries where these programs are not available continue to experience high rates of CC deaths. In early-stage CC, the primary treatment is surgery or radiotherapy, whereas concurrent chemo-radiotherapy (CRT) remains the conventional approach in locally advanced stages until the upcoming approval of immunotherapy. The incorporation of immunotherapy in combination with chemotherapy (with or without bevacizumab) in first line and as monotherapy in second line after platinum-based chemotherapy, has significantly increased overall survival (OS) in recurrent or metastatic CC. The purpose of this guideline is to summarize the most relevant evidence in the diagnosis, treatment, and follow-up of CC and to provide evidence-based recommendations for clinical practice.

Keywords: Cervical cancer; Diagnosis; Guideline; Treatment.

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Conflict of interest statement

ARV reports Advisory Board—Speaker grant from Eisai and AstraZeneca; Advisory Board—Speaker Grant from GSK and MSD, and Speaker fees from Roche. IR reports Advisory Board—Speaker Grant from AstraZeneca; Advisory Board – Other fees from PHARMAAND; Advisory Board—Speaker fees from Pharmamar; Advisory Board—Speaker—Grant—Other fees from GSK, and Speaker—Other fees from MSD. LSL reports Other fees from GSK, AstraZeneca, and MSD and Other fees from Roche and Pfizer. LFM reports Advisory Board—Speaker fees from GSK and Speake fees from Astrazeneca, MSD, Eisai, and Pharmand. YGG reports Advisory Board fees from Roche and Speaker—Other fees from MSD and GSK. MGM reports Speaker—Other fees from GSK and MSD; Speaker fees from Clovis, and Advisory Board—Speaker—Other fess from AstraZeneca. LM, MDBP, PEG, y MQ have nothing to disclose.

Figures

Fig. 1
Fig. 1
Recurrent and metastatic disease
See this image and copyright information in PMC

References

    1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63. - PubMed
    1. Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169–82. - PubMed
    1. Joura EA, Giuliano AR, Iversen O-E, Bouchard C, Mao C, Mehlsen J, et al. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. N Engl J Med. 2015;372(8):711–23. - PubMed
    1. Perkins RB, Wentzensen N, Guido RS, Schiffman M. Cervical cancer screening: a review. JAMA. 2023;330(6):547–58. - PubMed
    1. Ronco G, Dillner J, Elfström KM, Tunesi S, Snijders PJF, Arbyn M, et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. Lancet. 2014;383(9916):524–32. - PubMed

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