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Comment
. 2024 Oct;102(9):757-759.
doi: 10.1111/imcb.12818. Epub 2024 Sep 1.

Unraveling the origins of pathogenic CXCL13+ helper T cells in systemic lupus erythematosus

Sam Nettelfield  1 , Zhian Chen  1
Affiliations
Comment

Unraveling the origins of pathogenic CXCL13+ helper T cells in systemic lupus erythematosus

Sam Nettelfield et al. Immunol Cell Biol. 2024 Oct.

Abstract

This Research Highlight discusses a recent publication, where the authors identified an increase in CXCL13+ peripheral helper T/follicular helper T cells, which was concomitant with a decrease in CD96+ T helper 22 (TH22) cells in patients with systemic lupus erythematosus. The genetic and epigenetic cues that reciprocally regulate this pathogenic imbalance of T-cell subsets were also identified, thus providing targets for therapeutic intervention.

Keywords: Inflammatory response; pathogenic CXCL13+ helper T cells; systemic lupus erythematosus.

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  • Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
    Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE; Accelerating Medicines Partnership: RA/SLE Network; Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA. Law C, et al. Nature. 2024 Jul;631(8022):857-866. doi: 10.1038/s41586-024-07627-2. Epub 2024 Jul 10. Nature. 2024. PMID: 38987586 Free PMC article.

References

REFERENCES

    1. Kaul A, Gordon C, Crow MK, et al. Systemic lupus erythematosus. Nat Rev Dis Primers 2016; 2: 16039.
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    1. Law C, Wacleche VS, Cao Y, et al. Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus. Nature 2024; 631: 857–866.

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