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Comparative Study
. 1985 Apr;314(6012):592-7.
doi: 10.1038/314592a0.

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

A Chomyn, P Mariottini, M W Cleeter, C I Ragan, A Matsuno-Yagi, Y Hatefi, R F Doolittle, G Attardi
Comparative Study

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

A Chomyn et al. Nature. 1985 Apr.

Abstract

The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NADH-K3Fe(CN)6 oxidoreductase activities. We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase.

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