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. 2025 Feb;47(1):123-133.
doi: 10.1111/ics.13017. Epub 2024 Sep 1.

Regulation of dermal circadian pathways by a novel topical formulation

Charlene DeHaven  1 , Stephanie Wheeler  2 , Anna Langerveld  2 , C Bryan Johns  1
Affiliations

Regulation of dermal circadian pathways by a novel topical formulation

Charlene DeHaven et al. Int J Cosmet Sci. 2025 Feb.

Abstract
in English, French

Skin health is impacted by a wide range of intrinsic and extrinsic factors (J Dermatol Sci, 2017, 85, 152), including those that impact circadian rhythm, such as sleep disruption (Textbook of Aging Skin, 2016), UV (Biomed Aging Pathol, 2013, 3, 161) and blue light (Int J Cosmet Sci, 2019, 41, 558). Disruption of the skin's endogenous circadian balance, even by a consistently late bedtime, has deleterious effects on multiple measurements of skin health, including hydration, skin barrier protection, microbiome counts and skin regeneration, among others (Clin Cosmet Investig Dermatol, 2022, 15, 1051). Skin repair processes occur at night and help to maintain important aspects of skin health (FEBS Lett, 2021, 595, 2413). Interest is increasing in the development of topical products that help restore proper circadian function. This study demonstrates that a proprietary topical formulation regulates new and established gene and protein biomarkers of circadian entrainment and circadian rhythm, demonstrating the product's potential to maintain appropriate dermal diurnal balance.

La santé de la peau est affectée par un large éventail de facteurs intrinsèques et extrinsèques (J Dermatol Sci, 2017, 85, 152), y compris ceux qui ont un impact sur le rythme circadien, tels que les troubles du sommeil (Textbook of Aging Skin, 2016), les UV (Biomed Aging Pathol, 2013, 3, 161) et la lumière bleue (Int J Cosmet Sci, 2019, 41, 558). La perturbation du rythme circadien endogène de la peau, même par un coucher systématiquement tardif, a des effets délétères sur de multiples mesures de la santé de la peau, notamment l’hydratation, la protection de la barrière cutanée, le nombre de microbiomes et la régénération de la peau, entre autres (Clin Cosmet Investig Dermatol, 2022, 15, 1051). Les processus de réparation de la peau se produisent la nuit et aident à maintenir les aspects importants de la santé de la peau (FEBS Lett, 2021, 595, 2413). L’intérêt est accru dans le développement de produits topiques qui aident à restaurer une fonction circadienne correcte. Cette étude démontre qu’une formulation topique exclusive régule les biomarqueurs génétiques et protéiques nouveaux et établis de l’entraînement circadien et du rythme circadien, ce qui montre le potentiel du produit à maintenir un équilibre diurne cutané approprié.

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Figures

FIGURE 1
FIGURE 1
Summary of differentially expressed genes.
FIGURE 2
FIGURE 2
Circadian entrainment. Image adapted from KEGG submission for #04713, Kanehisa Laboratories, 28 January 2019. Only genes regulated in this study are shown; n.s., not significant. [Colour figure can be viewed at wileyonlinelibrary.com]
FIGURE 3
FIGURE 3
Circadian rhythm. Image adapted from KEGG submission for #04710, Kanehisa Laboratories, 02 August 2022. Only genes regulated in this study are shown; n.s., not significant. [Colour figure can be viewed at wileyonlinelibrary.com]
FIGURE 4
FIGURE 4
Gene regulation by TMX and TMY at 32, 40 and 48 h. (a) Upregulated genes; (b) Downregulated genes; (c) Genes which showed cycling, that is, early upregulation and later downregulation. * indicates significance (p < 0.05) versus time‐matched saline control. [Colour figure can be viewed at wileyonlinelibrary.com]
FIGURE 5
FIGURE 5
(a) CALM1. (b) cFOS. (c) GNG11. (d) GUCY1A1. (e) PER2. [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

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