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Case Reports
. 2024 Aug 29;12(9):e9352.
doi: 10.1002/ccr3.9352. eCollection 2024 Sep.

Recurrence of valvular involvement in Libman-Sacks endocarditis associated with antiphospholipid syndrome: A case report

Shahab Masoumi  1 , Razieh Parizad  1 , Rezayat Parvizi  1 , Amirreza Jabbaripour Sarmadian  1 , Samira Jafarisis  1 , Kia Seyed Toutounchi  2
Affiliations
Case Reports

Recurrence of valvular involvement in Libman-Sacks endocarditis associated with antiphospholipid syndrome: A case report

Shahab Masoumi et al. Clin Case Rep. .

Abstract

Key clinical message: Recurrence of valvular involvement may occur after Libman-Sacks endocarditis surgery, emphasizing the need for frequent multivalvular evaluations with echocardiography or more sensitive methods to optimize surgical outcomes.

Abstract: This report presented a 32-year-old woman, complaining of recurrent fever and chills. Physical examination revealed the presence of a third heart sound (S3), a pan-systolic murmur (III/VI) at mitral and tricuspid foci, tachycardia, and fine pulmonary crackles. Transesophageal echocardiography (TEE) revealed severe mitral regurgitation (MR) and moderate tricuspid regurgitation (TR) with vegetations on the mitral valve. Initially, intravenous antibiotic therapy was started simultaneously with diagnostic studies. Despite a positive TEE, negative blood cultures on three separate occasions precluded meeting the diagnostic criteria outlined in the modified Duke criteria. Moreover, the patient's condition continued to deteriorate after antibiotic therapy, leading to the diagnosis of Libman-Sacks endocarditis. The patient was considered a candidate for mitral valve surgery. All vegetations were completely debrided and then the mitral valve was reconstructed. Follow-up post-surgery echocardiography revealed the absence of MR and mitral stenosis (MS). Four months later, the patient presented again complaining of fatigue, dyspnea, lower extremity edema, and ascites with evidence of pulmonary hypertension and right heart failure on physical examination. TEE was performed, which revealed severe MR, severe TR, detached artificial chordae, and blood leak from the perforated pericardial patch. Therefore, she was necessitated for valvular surgery and underwent mitral and tricuspid valve surgery. The mitral ring and perforated pericardial patch were removed, and a mitral prosthetic valve was implanted. In addition, the tricuspid valve was repaired. Follow-up post-surgery echocardiography revealed the absence of MR and TR. To our knowledge, this is the first case of LSE recurrence with multi-valvular involvement.

Keywords: Libman–Sacks endocarditis; antiphospholipid syndrome; case report; heart valve diseases.

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Conflict of interest statement

The authors declare no financial and non‐financial competing interests related to this work.

Figures

FIGURE 1
FIGURE 1
2D‐TEE mitral valve view demonstrating vegetations (White arrows).
FIGURE 2
FIGURE 2
2D‐TEE mitral valve view demonstrating perforated pericardial patch (White arrows).
See this image and copyright information in PMC

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