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Case Reports
. 2024 Jul 26:12:100411.
doi: 10.1016/j.ijregi.2024.100411. eCollection 2024 Sep.

A new case of Echovirus 11 neonatal fulminant hepatitis involving male twins in a Northern Italy Tertiary University Hospital: Insight on a possible immunological clue

Federica Novazzi  1   2 , Antonio Piralla  3 , Simona Perniciaro  4 , Angelo Paolo Genoni  1   2 , Francesca Drago Ferrante  2 , Federica Giardina  5 , Guglielmo Ferrari  3 , Laura Pellegrinelli  6 , Nicola Clementi  7 , Elena Pariani  6 , Ivan Zanoni  8 , Fausto Baldanti  3   5 , Massimo Agosti  9 , Nicasio Mancini  1   2
Affiliations
Case Reports

A new case of Echovirus 11 neonatal fulminant hepatitis involving male twins in a Northern Italy Tertiary University Hospital: Insight on a possible immunological clue

Federica Novazzi et al. IJID Reg. .

Abstract

The European Center for Disease Prevention and Control has reported 19 cases of severe echovirus 11 infections in neonates since 2022, nine of which were fatal. We report a new fatal neonatal case that occurred in a male twin for which we evaluated the respiratory and intestinal mucosal innate immune response.

Keywords: Echovirus 11; Enterovirus; Hepatitis; Mucosal immunity; Neonatal infection.

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Conflict of interest statement

The authors have no competing interests to declare.

Figures

Figure 1(a)
Figure 1(a)
The mucosal expression of innate immune mediators parallels EV load in respiratory samples of infected newborns.
Figure 1(b)
Figure 1(b)
The mucosal expression of innate immune mediators is lower in the newborn with a fatal outcome, suggesting the ineffective primary control of EV replication at the gastrointestinal level.
See this image and copyright information in PMC

References

    1. European Centre for Disease Prevention and Control (ECDC). Epidemiological update: echovirus 11 infections in neonates 19 July 2023, https://www.ecdc.europa.eu/en/news-events/epidemiological-update-echovir...; 2023 [accessed 19 July 2023].
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