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. 2024 Aug 16:15:1428411.
doi: 10.3389/fendo.2024.1428411. eCollection 2024.

Global research trends and hotspots of oxidative stress in diabetic retinopathy (2000-2024)

Kejie Du #  1 , Yichong Liu #  1 , Xintong Zhao #  1 , Haowen Wang  1 , Xiaomei Wan  1 , Xiaoyan Sun  1 , Wenjuan Luo  1
Affiliations

Global research trends and hotspots of oxidative stress in diabetic retinopathy (2000-2024)

Kejie Du et al. Front Endocrinol (Lausanne). .

Abstract

Introduction: Oxidative stress has been identified as a major contributor to the pathogenesis of DR, and many diagnostic and therapeutic strategies have been developed to target oxidative stress. Our aim was to understand the contribution of the country of origin of the publication, the institution, the authors, and the collaborative relationship between them.

Methods: We performed a bibliometric analysis to summarize and explore the research hotspots and trends of oxidative stress in the DR.

Results: We observe an upward trend in the number of posts on related topics from year to year. Expanding on this, Queens University Belfast is the most influential research institution. Current research hotspots and trends focus on the mechanism of autophagy and NLRP3 inflammasome's role in oxidative stress in DR.

Discussion: We conducted a multi-dimensional analysis of the research status of oxidative stress in diabetic retinopathy through bibliometric analysis, and proposed possible future research trends and hotspots.

Keywords: NLRP3; autophagy; bibliometric analysis; diabetic retinopathy; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of data collection.
Figure 2
Figure 2
Line graph of annual publications.
Figure 3
Figure 3
National contributions to oxidative stress in diabetic retina research. (A) Geo-visualization to analyze cooperation among countries (B) Bar chart of annual publications for the top 10 countries with the highest number of publications (C) Visualization of chord plots of the share of publications by country and cooperation between countries.
Figure 4
Figure 4
Cooperation between agencies and issuance of communications. (A) Collaboration between major institutions, with the threshold for institutional issuance set at 8 (B) Number of articles and citations for the top 10 issuing organizations.
Figure 5
Figure 5
Visual analysis of publication authors and co-cited authors. (A) Number of publications by authors and cooperation between authors. Author posting volume threshold set at 5. (B) Collaboration and clustering of co-cited authors. Threshold set to 100. (C) Top five authors with the highest number of publications per year.
Figure 6
Figure 6
Visual analysis of references. (A) Clustering references by keywords. (B) Timeline analysis of the results of reference clustering. (C) Burst analysis of references. (D) Network visualization analysis and clustering of co-cited literature. Threshold set to 80.
Figure 7
Figure 7
Visual analysis of keywords and research hotspots. (A) word cloud of keywords. (B) Cluster analysis of keywords. (C) Keywords Heatmap. (D) Keyword network analysis. Threshold set to 6. (E) Burst analysis of keywords.
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