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. 2024 Nov;40(11):3553-3561.
doi: 10.1007/s00381-024-06579-2. Epub 2024 Sep 2.

Psychosocial and executive functioning late effects in pediatric brain tumor survivors after proton radiation

Julie A Grieco  1   2 , Casey L Evans  3   4 , Torunn I Yock  5   4 , Margaret B Pulsifer  3   4
Affiliations

Psychosocial and executive functioning late effects in pediatric brain tumor survivors after proton radiation

Julie A Grieco et al. Childs Nerv Syst. 2024 Nov.

Abstract

Purpose: Pediatric brain tumor survivors can experience detrimental effects from radiation treatment. This cross-sectional, large cohort study examined late psychosocial and executive functioning effects in pediatric patients treated ≥ 3 years after proton radiation therapy (PRT).

Methods: Parents of 101 pediatric brain tumor survivors completed the Behavior Assessment System for Children and the Behavior Rating Inventory of Executive Function. Standard scores were compared to published normative means, rates of impairment (T-score > 65) were calculated, and demographic and clinical characteristics were examined.

Results: Mean age at PRT was 8.12 years and mean interval from PRT to assessment was 6.05 years. Half were female (49.5%), 45.5% received craniospinal irradiation (CSI), and 58.4% were diagnosed with infratentorial tumors. All mean T-scores were within normal range. Mean T-scores were significantly elevated compared to the norm on the withdrawal, initiate, working memory, and plan/organize scales. Rates of impairment were notably high in working memory (24.8%), initiate (20.4%), withdrawal (18.1%), and plan/organize (17.0%). Greater withdrawal was significantly associated with CSI and also with chemotherapy and diagnosis of hearing loss. Mean T-scores were significantly lower than the norm on the hyperactivity, aggression, conduct problems, and inhibition scales. No significant problems were identified with social skills or depression. Interval since treatment was not correlated with any scale.

Conclusion: Although psychosocial and executive functioning was within the normal range, on average, social withdrawal and metacognitive executive functioning (working memory, initiating, planning/organizing) were areas of concern. Targeted yearly screening and proactive executive skill and social interventions are needed for this population.

Keywords: Brain tumor; Executive functioning; Late effects of cancer treatment; Proton radiation; Psychosocial.

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