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Review
. 2024 Oct;50(10):1580-1592.
doi: 10.1007/s00134-024-07586-2. Epub 2024 Sep 2.

Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis

Massimo Girardis  1 , Sascha David  2 , Ricard Ferrer  3 , Julie Helms  4 , Nicole P Juffermans  5 , Ignacio Martin-Loeches  6   7 , Pedro Povoa  8   9   10 , Lene Russell  11   12 , Manu Shankar-Hari  13   14 , Toshiaki Iba  15 , Irene Coloretti  16 , Nicholas Parchim  17 , Nathan D Nielsen  17
Affiliations
Review

Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis

Massimo Girardis et al. Intensive Care Med. 2024 Oct.

Abstract

The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.

Keywords: Coagulation; Endothelium; Immune system; Sepsis.

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References

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