Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 2;9(9):837-844.
doi: 10.1530/EOR-24-0084.

Advanced therapies in orthopaedics

Tobias Winkler  1   2   3 , Sven Geissler  2   3 , Tazio Maleitzke  3   4   5 , Carsten Perka  1 , Georg N Duda  1   2   3 , Alexander Hildebrandt  1   2
Affiliations
Review

Advanced therapies in orthopaedics

Tobias Winkler et al. EFORT Open Rev. .

Abstract

Advanced therapies are expected to play a crucial role in supporting repair after injury, halting the degeneration of musculoskeletal tissue to enable and promote physical activity. Despite advancements, the progress in developing advanced therapies in orthopaedics lags behind specialties like oncology, since innovative regenerative treatment strategies fall short of their expectations in musculoskeletal clinical trials. Researchers should focus on understanding the mechanism of action behind the investigated target before conducting clinical trials. Strategic research networks are needed that not only enhance scientific exchange among like-minded researchers but need to include early on commercial views, companies and venture perspectives, regulatory insights and reimbursement perspectives. Only in such collaborations essential roadblocks towards clinical trials and go-to-patients be overcome.

Keywords: advanced therapies; biomaterials; cell therapy; degeneration; gene therapy; orthobiologics.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the study reported.

References

    1. Grosso MJ Neuwirth AL Boddapati V Shah RP Cooper HJ & Geller JA. Decreasing length of hospital stay and postoperative complications after primary total hip arthroplasty: a decade analysis from 2006 to 2016. Journal of Arthroplasty 201934422–425. (10.1016/j.arth.2018.11.005) - DOI - PubMed
    1. Mamdouhi T Wang V Echevarria AC Katz A Morris M Zavurov G & Verma R. A comprehensive review of the historical description of spine surgery and its evolution. Cureus 202416e54461. (10.7759/cureus.54461) - DOI - PMC - PubMed
    1. Vogt B Rupp C Gosheger G Eveslage M Laufer A Toporowski G Roedl R & Frommer A. A clinical and radiological matched-pair analysis of patients treated with the PRECICE and STRYDE magnetically driven motorized intramedullary lengthening nails. Bone and Joint Journal 2023105–B88–96. (10.1302/0301-620X.105B1.BJJ-2022-0755.R1) - DOI - PubMed
    1. Meyer DC Bachmann E Darwiche S Moehl A von Rechenberg B Gerber C & Snedeker JG. Rotator cuff repair and overlay augmentation by direct interlocking of a nonwoven polyethylene terephthalate patch into the tendon: evaluation in an ovine model. American Journal of Sports Medicine 2023513235–3242. (10.1177/03635465231189802) - DOI - PubMed
    1. Epari DR Gurung R Hofmann-Fliri L Schwyn R Schuetz M & Windolf M. Biphasic plating improves the mechanical performance of locked plating for distal femur fractures. Journal of Biomechanics 2021115110192. (10.1016/j.jbiomech.2020.110192) - DOI - PubMed

LinkOut - more resources