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. 2024 Aug 10;10(16):e36127.
doi: 10.1016/j.heliyon.2024.e36127. eCollection 2024 Aug 30.

Bibliometric analysis of research on osteoarthritis and extracellular vesicles: Trends and frontiers

Yongkang Ding  1 , Lu Liang  2 , Ye Guo  1 , Bing Zhu  2
Affiliations

Bibliometric analysis of research on osteoarthritis and extracellular vesicles: Trends and frontiers

Yongkang Ding et al. Heliyon. .

Abstract

Extensive research has made significant progress in exploring the potential application of extracellular vesicles (EV) in the diagnosis and treatment of osteoarthritis (OA). However, there is current a lack of study on bibliometrics. In this study, we completed a novel bibliometric analysis of EV research in OA over the past two decades. Specifically, we identified a total of 354 relevant publications obtained between January 1, 2003 and December 31, 2022. We also provided a description of the distribution information regarding the countries or regions of publication, institutions involved, journals, authors, citations, and keywords. The primary research focuses encompassed the role of extracellular vesicles in the diagnosis of OA, delivery of active ingredients, treatment strategies, and cartilage repair. These findings highlight the latest research frontiers and emerging areas, providing valuable insights for further investigations on the application of extracellular vesicles in the context of osteoarthritis.

Keywords: Bibliometrics; Data visualization; Extracellular vesicles; Osteoarthritis; Research hotspot.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flow chart of data collection.
Fig. 2
Fig. 2
Number of annual publications on extracellular vesicles in osteoarthritis from 2003 to 2022.
Fig. 3
Fig. 3
Contributions of various countries to the study of extracellular vesicles in osteoarthritis (A) National scientific production and geographical distribution. (B) Total citations, average citations and H-index of the top 10 countries contributing to publications.
Fig. 4
Fig. 4
Network map from different countries or regions regarding extracellular vesicles in osteoarthritis. (A) Cooperation between countries or regions based on VOSviewer. (B) Dynamics and trends of countries over time. (C) Density map of country distribution of published articles based on VOSviewer.
Fig. 5
Fig. 5
Visualization of extracellular vesicle research institutions in osteoarthritis. (A) Analysis of institutional cooperation network based on VOSviewer. (B) Over time, the dynamics and trends of institutions.
Fig. 6
Fig. 6
The dual-map overlay of journals on research of exosomes in osteoarthritis.
Fig. 7
Fig. 7
Visualization of authors and co-cited authors involved in extracellular vesicles of osteoarthritis. (A) The network map of productive authors. (B) Co-citation network of authors.
Fig. 8
Fig. 8
References with citation burst and veen outline (A) 20 references with the strongest citation burst. (B) Veen outline of highly cited, co cited, and explosive cited papers.
Fig. 9
Fig. 9
Keyword localization in the study of extracellular vesicles in osteoarthritis. (B) Visualization map of keywords clustering on engineered exosomes This map constituted by 58 items, including red clusters (18 items), green clusters (17 items) and blue clusters (14 items) and yellow clusters (9 items). (B) Timeline visualization of high-frequency topic keywords from 2006 to 2022. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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