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Case Reports
. 2024 Aug 15:24:e45.
eCollection 2024.

Mixed Neuroendocrine-Squamous Cell Carcinoma of the Hand With Metastatic Dissemination: A Case Report

Jubril Adepoju  1   2 , John A Toms 3rd  1   2 , Elizabeth S O'Neill  1   2 , Mark Grievous  1   2 , Jafar Hasan  1   2 , Christina Tragos  1   2 , Matthew Doscher  1   2
Affiliations
Case Reports

Mixed Neuroendocrine-Squamous Cell Carcinoma of the Hand With Metastatic Dissemination: A Case Report

Jubril Adepoju et al. Eplasty. .

Abstract

Cutaneous manifestations of mixed neuroendocrine non-neuroendocrine neoplasms remain a diagnostic rarity. Predominantly identified within internal glandular organs, the digestive tract, and in the hepatobiliary system, this case report illustrates a unique occurrence of a mixed squamous cell and neuroendocrine tumor in the index finger of a justice-affected patient. We discuss the complexities of diagnosis and complications as well as emphasize the importance for hand surgeons to recognize presentations like this and the need for vigilant follow-up and improved care coordination.

Keywords: Merkel Cell Cancer; Neuroendocrine tumors; hand surgery; plastic surgery; squamous cell carcinoma.

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Figures

Figure 1
Figure 1
Radiographic images obtained prior to surgery demonstrating lucency and cortical erosion of the distal phalanx and distal portion of the middle phalanx of the left index finger consistent with osteomyelitis. (A) posteroanterior view, (B) lateral view.
Figure 2
Figure 2
Purulent and necrotic wound of distal phalanx of the left index finger.
Figure 3
Figure 3
Hematoxylin and eosin stain demonstrating squamous cell carcinoma (black arrow) and neuroendocrine carcinoma (blue arrow).
Figure 4
Figure 4
Immunohistochemical stains: (A) squamous cocktail, positive in squamous cell carcinoma, (B) P16, positive in squamous cell carcinoma, (C) Hematoxylin and eosin stain of neuroendocrine tumor, (D) Synaptophysin positive in neuroendocrine tumor.
See this image and copyright information in PMC

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