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Case Reports
. 2024 Aug 2;16(8):e66045.
doi: 10.7759/cureus.66045. eCollection 2024 Aug.

Unveiling the Uncommon: A Case Series on Cushing's Disease During Pregnancy

Ravi Shah  1 , Subin S  1 , Vanita Suri  2 , Sanjay K Bhadada  1 , Rama Walia  1
Affiliations
Case Reports

Unveiling the Uncommon: A Case Series on Cushing's Disease During Pregnancy

Ravi Shah et al. Cureus. .

Abstract

Cushing's disease (CD) is characterized by a high rate of hypogonadism and infertility. It is difficult to detect CD in pregnant women who present with symptoms such as weight gain, striae, headache, backache, and pedal edema that overlap with the physiological changes of pregnancy. In this paper, we present three cases of CD likely missed during pregnancy and later also discuss the approach to diagnosis and management of CD in pregnancy.

Keywords: cushing disease; cushing syndrome; pregnancy; striae; suppression test.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. (a) Case 1: Thin purplish striae over the patient's abdomen. (b) Case 1: post-contrast T1 weighted MRI image suggestive of pituitary microadenoma (yellow arrow). (c) Case 2 post-contrast T1 weighted CEMR of pituitary and hypothalamic area suggestive of residual pituitary microadenoma (yellow arrow) with distorted sellar anatomy due to previous surgery. (d) Case 3: Post-contrast T1-weighted CEMR pituitary and hypothalamic area suggestive of pituitary macroadenoma (yellow arrow)
CEMR: Contrast-enhanced magnetic resonance imaging
See this image and copyright information in PMC

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